Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:115617718" >
Keratinocyte growth...
Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques
-
Seggewiss, R (författare)
-
- Lore, K (författare)
- Karolinska Institutet
-
Guenaga, FJ (författare)
-
visa fler...
-
Pittaluga, S (författare)
-
Mattapallil, J (författare)
-
Chow, CK (författare)
-
Koup, RA (författare)
-
Camphausen, K (författare)
-
Nason, MC (författare)
-
Meier-Schellersheim, M (författare)
-
Donahue, RE (författare)
-
Blazar, BR (författare)
-
Dunbar, CE (författare)
-
Douek, DC (författare)
-
visa färre...
-
(creator_code:org_t)
- American Society of Hematology, 2007
- 2007
- Engelska.
-
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 110:1, s. 441-449
- Relaterad länk:
-
https://europepmc.or...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Opportunistic infections contribute to morbidity and mortality after peripheral blood progenitor cell (PBPC) transplantation and are related to a deficient T-cell compartment. Accelerated T-cell reconstitution may therefore be clinically beneficent. Keratinocyte growth factor (KGF) has been shown to protect thymic epithelial cells in mice. Here, we evaluated immune reconstitution after autologous CD34+ PBPC transplantation in rhesus macaques conditioned with myeloablative total body irradiation in the absence or presence of single pretotal body irradiation or repeated peritransplant KGF administration. All KGF-treated animals exhibited a well-preserved thymic architecture 12 months after graft. In contrast, thymic atrophy was observed in the majority of animals in the control group. The KGF-treated animals showed higher frequencies of naive T cells in lymph nodes after transplantation compared with the control animals. The animals given repeated doses of KGF showed the highest levels of T-cell receptor excision circles (TRECs) and the lowest frequencies of Ki67+ T cells, which suggest increased thymic-dependent reconstitution in these animals. Of note, the humoral response to a T-cell–dependent neo-antigen was significantly higher in the KGF-treated animals compared with the control animals. Thus, our findings suggest that KGF may be a useful adjuvant therapy to augment T-cell reconstitution after human PBPC transplantation.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Blood
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Seggewiss, R
-
Lore, K
-
Guenaga, FJ
-
Pittaluga, S
-
Mattapallil, J
-
Chow, CK
-
visa fler...
-
Koup, RA
-
Camphausen, K
-
Nason, MC
-
Meier-Schellersh ...
-
Donahue, RE
-
Blazar, BR
-
Dunbar, CE
-
Douek, DC
-
visa färre...
- Artiklar i publikationen
-
Blood
- Av lärosätet
-
Karolinska Institutet