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The graft-versus-le...
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Ringden, OKarolinska Institutet
(author)
The graft-versus-leukemia effect using matched unrelated donors is not superior to HLA-identical siblings for hematopoietic stem cell transplantation
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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American Society of Hematology,2009
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:118495189
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http://kipublications.ki.se/Default.aspx?queryparsed=id:118495189URI
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https://doi.org/10.1182/blood-2008-07-163212DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Do some patients benefit from an unrelated donor (URD) transplant because of a stronger graft-versus-leukemia (GVL) effect? We analyzed 4099 patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic myeloid leukemia (CML) undergoing a myeloablative allogeneic hematopoietic cell transplantation (HCT) from an URD (8/8 human leukocyte antigen [HLA]–matched, n = 941) or HLA-identical sibling donor (n = 3158) between 1995 and 2004 reported to the CIBMTR. In the Cox regression model, acute and chronic GVHD were added as time-dependent variables. In multivariate analysis, URD transplant recipients had a higher risk for transplantation-related mortality (TRM; relative risk [RR], 2.76; P < .001) and relapse (RR, 1.50; P < .002) in patients with AML, but not ALL or CML. Chronic GVHD was associated with a lower relapse risk in all diagnoses. Leukemia-free survival (LFS) was decreased in patients with AML without acute GVHD receiving a URD transplant (RR, 2.02; P < .001) but was comparable to those receiving HLA-identical sibling transplants in patients with ALL and CML. In patients without GVHD, multivariate analysis showed similar risk of relapse but decreased LFS for URD transplants for all 3 diagnoses. In conclusion, risk of relapse was the same (ALL, CML) or worse (AML) in URD transplant recipients compared with HLA-identical sibling transplant recipients, suggesting a similar GVL effect.
Added entries (persons, corporate bodies, meetings, titles ...)
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Pavletic, SZ
(author)
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Anasetti, C
(author)
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Barrett, AJ
(author)
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Wang, T
(author)
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Wang, D
(author)
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Antin, JH
(author)
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Di Bartolomeo, P
(author)
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Bolwell, BJ
(author)
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Bredeson, C
(author)
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Cairo, MS
(author)
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Gale, RP
(author)
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Gupta, V
(author)
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Hahn, T
(author)
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Hale, GA
(author)
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Halter, J
(author)
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Jagasia, M
(author)
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Litzow, MR
(author)
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Locatelli, F
(author)
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Marks, DI
(author)
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McCarthy, PL
(author)
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Cowan, MJ
(author)
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Petersdorf, EW
(author)
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Russell, JA
(author)
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Schiller, GJ
(author)
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Schouten, H
(author)
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Spellman, S
(author)
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Verdonck, LF
(author)
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Wingard, JR
(author)
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Horowitz, MM
(author)
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Arora, M
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Blood: American Society of Hematology113:13, s. 3110-31181528-00200006-4971
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Ringden, O
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Pavletic, SZ
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Anasetti, C
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Barrett, AJ
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Wang, T
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Wang, D
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Antin, JH
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Di Bartolomeo, P
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Bolwell, BJ
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Bredeson, C
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Cairo, MS
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Gale, RP
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Gupta, V
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Hahn, T
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Hale, GA
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Halter, J
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Jagasia, M
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Litzow, MR
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Locatelli, F
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Marks, DI
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McCarthy, PL
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Cowan, MJ
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Petersdorf, EW
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Russell, JA
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Schiller, GJ
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Schouten, H
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Spellman, S
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Verdonck, LF
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Wingard, JR
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Horowitz, MM
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Arora, M
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Karolinska Institutet