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Plasma protein biom...
Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes
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Kiddle, SJ (författare)
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Steves, CJ (författare)
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Mehta, M (författare)
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visa fler...
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- Simmons, A (författare)
- Karolinska Institutet
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Xu, X (författare)
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Newhouse, S (författare)
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Sattlecker, M (författare)
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Ashton, NJ (författare)
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Bazenet, C (författare)
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Killick, R (författare)
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Adnan, J (författare)
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- Westman, E (författare)
- Karolinska Institutet
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Nelson, S (författare)
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Soininen, H (författare)
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Kloszewska, I (författare)
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Mecocci, P (författare)
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Tsolaki, M (författare)
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Vellas, B (författare)
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Curtis, C (författare)
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Breen, G (författare)
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Williams, SCR (författare)
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Lovestone, S (författare)
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Spector, TD (författare)
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Dobson, RJB (författare)
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(creator_code:org_t)
- 2015-06-16
- 2015
- Engelska.
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Ingår i: Translational psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 5, s. e584-
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- There is great interest in blood-based markers of Alzheimer’s disease (AD), especially in its pre-symptomatic stages. Therefore, we aimed to identify plasma proteins whose levels associate with potential markers of pre-symptomatic AD. We also aimed to characterise confounding by genetics and the effect of genetics on blood proteins in general. Panel-based proteomics was performed using SOMAscan on plasma samples from TwinsUK subjects who are asymptomatic for AD, measuring the level of 1129 proteins. Protein levels were compared with 10-year change in CANTAB-paired associates learning (PAL; n=195), and regional brain volumes (n=34). Replication of proteins associated with regional brain volumes was performed in 254 individuals from the AddNeuroMed cohort. Across all the proteins measured, genetic factors were found to explain ~26% of the variability in blood protein levels on average. The plasma level of the mitogen-activated protein kinase (MAPK) MAPKAPK5 protein was found to positively associate with the 10-year change in CANTAB-PAL in both the individual and twin difference context. The plasma level of protein MAP2K4 was found to suggestively associate negatively (Q<0.1) with the volume of the left entorhinal cortex. Future studies will be needed to assess the specificity of MAPKAPK5 and MAP2K4 to eventual conversion to AD.
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- art (ämneskategori)
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- Av författaren/redakt...
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Kiddle, SJ
-
Steves, CJ
-
Mehta, M
-
Simmons, A
-
Xu, X
-
Newhouse, S
-
visa fler...
-
Sattlecker, M
-
Ashton, NJ
-
Bazenet, C
-
Killick, R
-
Adnan, J
-
Westman, E
-
Nelson, S
-
Soininen, H
-
Kloszewska, I
-
Mecocci, P
-
Tsolaki, M
-
Vellas, B
-
Curtis, C
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Breen, G
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Williams, SCR
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Lovestone, S
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Spector, TD
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Dobson, RJB
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visa färre...
- Artiklar i publikationen
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Translational ps ...
- Av lärosätet
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Karolinska Institutet