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Telomere Attrition ...
Telomere Attrition and Elongation after Chronic Dialysis Initiation in Patients with End-Stage Renal Disease
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Kato, S (författare)
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Shiels, PG (författare)
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McGuinness, D (författare)
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- Lindholm, B (författare)
- Karolinska Institutet
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- Stenvinkel, P (författare)
- Karolinska Institutet
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- Nordfors, L (författare)
- Karolinska Institutet
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- Qureshi, AR (författare)
- Karolinska Institutet
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Yuzawa, Y (författare)
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Matsuo, S (författare)
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Maruyama, S (författare)
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(creator_code:org_t)
- 2015-10-20
- 2016
- Engelska.
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Ingår i: Blood purification. - : S. Karger AG. - 1421-9735 .- 0253-5068. ; 41:1-3, s. 25-33
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- <b><i>Aims:</i></b> To analyze changes in telomere length (TL) after dialysis initiation. <b><i>Methods:</i></b> In 59 Japanese incident dialysis patients, associations between TL in peripheral blood leukocytes, inflammatory biomarkers and nutritional status at baseline and changes in TL during 1 year of dialysis, were investigated. <b><i>Results:</i></b> Whereas relative TL decreased by 8.6% (median 14.4%), TL elongation occurred in 16 patients (27%). Change in TL (ΔTL), defined as TL at 1 year minus TL at baseline, was associated with baseline TL (ρ = -0.70, p < 0.0001) and leukocyte count (ρ = 0.26, p = 0.044). In a logistic regression model, baseline TL (p < 0.0001) and leukocyte count (p = 0.047) were associated with ΔTL. <b><i>Conclusions:</i></b> TL shortening was observed in most incident dialysis patients. In 16 of the 59 patients, TL elongation occurred, possibly reflecting a more robust biological aging in patients whose naïve leukocytes may have undergone less proliferation to replace lost leukocytes.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Kato, S
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Shiels, PG
-
McGuinness, D
-
Lindholm, B
-
Stenvinkel, P
-
Nordfors, L
-
visa fler...
-
Qureshi, AR
-
Yuzawa, Y
-
Matsuo, S
-
Maruyama, S
-
visa färre...
- Artiklar i publikationen
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Blood purificati ...
- Av lärosätet
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Karolinska Institutet