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Immunization with H...
Immunization with HER2 extracellular subdomain proteins induces cellular response and tumor growth inhibition in mice
- Article/chapterEnglish2018
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:138391840
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138391840URI
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https://doi.org/10.2217/imt-2017-0181DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Aim: We investigated cellular and protective immune responses in mice vaccinated with recombinant HER2 extracellular subdomains. Materials & methods: Balb/C mice were immunized with recombinant full HER2 extracellular domain and subdomain proteins. Humoral and cellular immune response and antitumor effect was evaluated using a syngeneic mice tumor model. Results: All recombinant proteins induced secretion of IL-4 and particularly IFN-γ and IL-17 cytokines. Challenging of immunized mice with stable 4T1-HER2 transfected cells resulted in partial but significant tumor growth inhibition in all groups of mice particularly those immunized with fHER2-ECD together with CPG. Conclusion: Our results suggest that the recombinant HER2-ECD subdomains induce mainly Th1 and Th17 responses, which seem to contribute to tumor growth inhibition in syngeneic mice.
Added entries (persons, corporate bodies, meetings, titles ...)
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Sadri-Ardalani, F
(author)
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Amiri, MM
(author)
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Jeddi-Tehrani, MKarolinska Institutet
(author)
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Shabani, M
(author)
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Shokri, F
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Immunotherapy: Future Medicine Ltd10:6, s. 511-5241750-74481750-743X
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