Search: onr:"swepub:oai:prod.swepub.kib.ki.se:138441853" >
Interplay between h...
Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice
-
Tunon, J (author)
-
- Back, M (author)
- Karolinska Institutet
-
Badimon, L (author)
-
show more...
-
Bochaton-Piallat, ML (author)
-
Cariou, B (author)
-
Daemen, MJ (author)
-
Egido, J (author)
-
Evans, PC (author)
-
Francis, SE (author)
-
- Ketelhuth, DFJ (author)
- Karolinska Institutet
-
Lutgens, E (author)
-
Matter, CM (author)
-
Monaco, C (author)
-
Steffens, S (author)
-
Stroes, E (author)
-
Vindis, C (author)
-
Weber, C (author)
-
Hoefer, IE (author)
-
show less...
-
(creator_code:org_t)
- 2018-05-14
- 2018
- English.
-
In: European journal of preventive cardiology. - : Oxford University Press (OUP). - 2047-4881 .- 2047-4873. ; 25:9, s. 948-955
- Related links:
-
https://academic.oup...
-
show more...
-
http://kipublication...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Dyslipidaemia and inflammation are closely interconnected in their contribution to atherosclerosis. In fact, low-density lipoprotein (LDL)-lowering drugs have anti-inflammatory effects. The Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) has shown that interleukin (IL)-1β blockade reduces the incidence of cardiovascular events in patients with previous myocardial infarction and C-reactive protein levels >2 mg/L. These data confirm the connection between lipids and inflammation, as lipids activate the Nod-like receptor protein 3 inflammasome that leads to IL-1β activation. LDL-lowering drugs are the foundation of cardiovascular prevention. Now, the CANTOS trial demonstrates that combining them with IL-1β blockade further decreases the incidence of cardiovascular events. However, both therapies are not at the same level, given the large evidence showing that LDL-lowering drugs reduce cardiovascular risk as opposed to only one randomized trial of IL-1β blockade. In addition, IL-1β blockade has only been studied in patients with C-reactive protein >2 mg/L, while the benefit of LDL-lowering is not restricted to these patients. Also, lipid-lowering drugs are not harmful even at very low ranges of LDL, while anti-inflammatory therapies may confer a higher risk of developing fatal infections and sepsis. In the future, more clinical trials are needed to explore whether targeting other inflammatory molecules, both related and unrelated to the IL-1β pathway, reduces the cardiovascular risk. In this regard, the ongoing trials with methotrexate and colchicine may clarify whether the cardiovascular benefit of IL-1β blockade extends to other anti-inflammatory mechanisms. A positive result would represent a major change in the future treatment of atherosclerosis.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Tunon, J
-
Back, M
-
Badimon, L
-
Bochaton-Piallat ...
-
Cariou, B
-
Daemen, MJ
-
show more...
-
Egido, J
-
Evans, PC
-
Francis, SE
-
Ketelhuth, DFJ
-
Lutgens, E
-
Matter, CM
-
Monaco, C
-
Steffens, S
-
Stroes, E
-
Vindis, C
-
Weber, C
-
Hoefer, IE
-
show less...
- Articles in the publication
-
European journal ...
- By the university
-
Karolinska Institutet