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Anticancer chemothe...
Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death
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Martins, I (författare)
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Raza, SQ (författare)
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Voisin, L (författare)
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Dakhli, H (författare)
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Allouch, A (författare)
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Law, F (författare)
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Sabino, D (författare)
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De Jong, D (författare)
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Thoreau, M (författare)
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Mintet, E (författare)
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Dugue, D (författare)
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Piacentini, M (författare)
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Gougeon, ML (författare)
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Jaulin, F (författare)
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Bertrand, P (författare)
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Brenner, C (författare)
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Ojcius, DM (författare)
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Kroemer, G (författare)
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Modjtahedi, N (författare)
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Deutsch, E (författare)
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Perfettini, JL (författare)
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- 2018-06-18
- 2018
- Engelska.
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Ingår i: Cell death & disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 9:7, s. 716-
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Even though cell death modalities elicited by anticancer chemotherapy and radiotherapy have been extensively studied, the ability of anticancer treatments to induce non-cell-autonomous death has never been investigated. By means of multispectral imaging flow-cytometry-based technology, we analyzed the lethal fate of cancer cells that were treated with conventional anticancer agents and co-cultured with untreated cells, observing that anticancer agents can simultaneously trigger cell-autonomous and non-cell-autonomous death in treated and untreated cells. After ionizing radiation, oxaliplatin, or cisplatin treatment, fractions of treated cancer cell populations were eliminated through cell-autonomous death mechanisms, while other fractions of the treated cancer cells engulfed and killed neighboring cells through non-cell-autonomous processes, including cellular cannibalism. Under conditions of treatment with paclitaxel, non-cell-autonomous and cell-autonomous death were both detected in the treated cell population, while untreated neighboring cells exhibited features of apoptotic demise. The transcriptional activity of p53 tumor-suppressor protein contributed to the execution of cell-autonomous death, yet failed to affect the non-cell-autonomous death by cannibalism for the majority of tested anticancer agents, indicating that the induction of non-cell-autonomous death can occur under conditions in which cell-autonomous death was impaired. Altogether, these results reveal that chemotherapy and radiotherapy can induce both non-cell-autonomous and cell-autonomous death of cancer cells, highlighting the heterogeneity of cell death responses to anticancer treatments and the unsuspected potential contribution of non-cell-autonomous death to the global effects of anticancer treatment.
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Till lärosätets databas
- Av författaren/redakt...
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Martins, I
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Raza, SQ
-
Voisin, L
-
Dakhli, H
-
Allouch, A
-
Law, F
-
visa fler...
-
Sabino, D
-
De Jong, D
-
Thoreau, M
-
Mintet, E
-
Dugue, D
-
Piacentini, M
-
Gougeon, ML
-
Jaulin, F
-
Bertrand, P
-
Brenner, C
-
Ojcius, DM
-
Kroemer, G
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Modjtahedi, N
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Deutsch, E
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Perfettini, JL
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visa färre...
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Cell death & dis ...
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Karolinska Institutet