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Anticancer chemothe...
Anticancer chemotherapy and radiotherapy trigger both non-cell-autonomous and cell-autonomous death
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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2018-06-18
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Springer Science and Business Media LLC,2018
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:138611283
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138611283URI
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https://doi.org/10.1038/s41419-018-0747-yDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Even though cell death modalities elicited by anticancer chemotherapy and radiotherapy have been extensively studied, the ability of anticancer treatments to induce non-cell-autonomous death has never been investigated. By means of multispectral imaging flow-cytometry-based technology, we analyzed the lethal fate of cancer cells that were treated with conventional anticancer agents and co-cultured with untreated cells, observing that anticancer agents can simultaneously trigger cell-autonomous and non-cell-autonomous death in treated and untreated cells. After ionizing radiation, oxaliplatin, or cisplatin treatment, fractions of treated cancer cell populations were eliminated through cell-autonomous death mechanisms, while other fractions of the treated cancer cells engulfed and killed neighboring cells through non-cell-autonomous processes, including cellular cannibalism. Under conditions of treatment with paclitaxel, non-cell-autonomous and cell-autonomous death were both detected in the treated cell population, while untreated neighboring cells exhibited features of apoptotic demise. The transcriptional activity of p53 tumor-suppressor protein contributed to the execution of cell-autonomous death, yet failed to affect the non-cell-autonomous death by cannibalism for the majority of tested anticancer agents, indicating that the induction of non-cell-autonomous death can occur under conditions in which cell-autonomous death was impaired. Altogether, these results reveal that chemotherapy and radiotherapy can induce both non-cell-autonomous and cell-autonomous death of cancer cells, highlighting the heterogeneity of cell death responses to anticancer treatments and the unsuspected potential contribution of non-cell-autonomous death to the global effects of anticancer treatment.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Raza, SQ
(författare)
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Voisin, L
(författare)
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Dakhli, H
(författare)
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Allouch, A
(författare)
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Law, F
(författare)
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Sabino, D
(författare)
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De Jong, D
(författare)
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Thoreau, M
(författare)
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Mintet, E
(författare)
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Dugue, D
(författare)
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Piacentini, M
(författare)
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Gougeon, ML
(författare)
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Jaulin, F
(författare)
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Bertrand, P
(författare)
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Brenner, C
(författare)
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Ojcius, DM
(författare)
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Kroemer, G
(författare)
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Modjtahedi, N
(författare)
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Deutsch, E
(författare)
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Perfettini, JL
(författare)
Sammanhörande titlar
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Ingår i:Cell death & disease: Springer Science and Business Media LLC9:7, s. 716-2041-4889
Internetlänk
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Till lärosätets databas
- Av författaren/redakt...
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Martins, I
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Raza, SQ
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Voisin, L
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Dakhli, H
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Allouch, A
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Law, F
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visa fler...
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Sabino, D
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De Jong, D
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Thoreau, M
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Mintet, E
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Dugue, D
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Piacentini, M
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Gougeon, ML
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Jaulin, F
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Bertrand, P
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Brenner, C
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Ojcius, DM
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Kroemer, G
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Modjtahedi, N
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Deutsch, E
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Perfettini, JL
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visa färre...
- Artiklar i publikationen
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Cell death & dis ...
- Av lärosätet
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Karolinska Institutet