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Outcomes of patient...
Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study
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- Elhai, M (author)
- Paris Descartes University,Carol Davila University of Medicine and Pharmacy
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- Boubaya, M (author)
- University of Paris VIII
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- Distler, O (author)
- University Hospital of Zurich
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show more...
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- Smith, V (author)
- Ghent University Hospital
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- Matucci-Cerinic, M (author)
- University of Florence
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- Sancho, JJ (author)
- Hospital Universitario Doctor Peset
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- Truchetet, ME (author)
- Centre Hospitalier Universitaire de Bordeaux
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- Braun-Moscovici, Y (author)
- Technion - Israel Institute of Technology
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- Iannone, F (author)
- University of Bari Aldo Moro
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- Novikov, PI (author)
- I.M. Sechenov First Moscow State Medical University
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- Lescoat, A (author)
- Rennes University Hospital
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- Siegert, E (author)
- Charité - University Medicine Berlin
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- Castellvi, I (author)
- Hospital de Sant Pau
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- Airo, P (author)
- Spedali Civili Di Brescia
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- Vettori, S (author)
- Second University of Napels
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- Langhe, E (author)
- Catholic University of Leuven
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- Hachulla, E (author)
- Lille University Hospital
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- Erler, A (author)
- Medizinsche Klinik und Poliklinik I, Dresden
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- Ananieva, L (author)
- V.A. Nasonova Research Institute of Rheumatology
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- Krusche, M (author)
- Asklepios Klinik Altona
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- Lopez-Longo, FJ (author)
- Hospital Universitario Quirón
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- Distler, JHW (author)
- Friedrich-Alexander University Erlangen-Nürnberg
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- Hunzelmann, N (author)
- University of Cologne
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- Hoffmann-Vold, AM (author)
- Norwegian Radium Hospital
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- Riccieri, V (author)
- Sapienza University of Rome
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- Hsu, VM (author)
- Rutgers University: The State University of New Jersey
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- Pozzi, MR (author)
- San Gerardo Hospital
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- Ancuta, C (author)
- Clinical Hospital Dr. Ion Cantacuzino
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- Rosato, E (author)
- Sapienza University of Rome
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Mihai, C (author)
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- Kuwana, M (author)
- Nippon Medical School
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- Saketkoo, LA (author)
- Tulane University
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- Chizzolini, C (author)
- Geneva University Hospital
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- Hesselstrand, Roger (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Systemic Sclerosis Research Group,Lund University Research Groups
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- Ullman, S (author)
- Copenhagen University Hospital
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- Yavuz, S (author)
- Marmara University
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- Rednic, S (author)
- University of Medicine and Pharmacy, Cluj-Napoca
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- Caimmi, C (author)
- University of Verona
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Bloch-Queyrat, C (author)
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- Allanore, Y (author)
- Paris Descartes University
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Guiducci, S (author)
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Walker, UA (author)
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Kyburz, D (author)
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Lapadula, G (author)
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Maurer, B (author)
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Jordan, S (author)
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Dobrota, R (author)
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Becvar, R (author)
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Sierakowsky, S (author)
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Bielecka, OK (author)
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Sulli, A (author)
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Cutolo, M (author)
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Cuomo, G (author)
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Nicoara, I (author)
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Kahan, A (author)
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Vlachoyiannopoulos, PG (author)
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Montecucco, CM (author)
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Caporali, R (author)
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Stork, J (author)
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Inanc, M (author)
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Carreira, PE (author)
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Novak, S (author)
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Czirjak, L (author)
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Varju, C (author)
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- Kucharz, EJ (author)
- Karolinska Institutet
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Kotulska, A (author)
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Kopec-Medrek, M (author)
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Widuchowska, M (author)
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Cozzi, F (author)
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Rozman, B (author)
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Mallia, C (author)
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Coleiro, B (author)
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Gabrielli, A (author)
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Farge, D (author)
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Wu, C (author)
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Marjanovic, Z (author)
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Faivre, H (author)
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Hij, D (author)
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Dhamadi, R (author)
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Wollheim, F (author)
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Scheja, A (author)
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Wuttge, DM (author)
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Andreasson, K (author)
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Martinovic, D (author)
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Balbir-Gurman, A (author)
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Trotta, F (author)
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Lo Monaco, A (author)
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Pellerito, R (author)
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Mauriziano, O (author)
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Caramaschi, P (author)
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Morovic-Vergles, J (author)
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Black, C (author)
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Denton, C (author)
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Damjanov, N (author)
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Henes, J (author)
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Santamaria, VO (author)
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Heitmann, S (author)
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Krasowska, D (author)
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, atthias (author)
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Hasler, P (author)
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Burkhardt, H (author)
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Himsel, A (author)
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Bajocchi, G (author)
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Da Silva, JAP (author)
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Salvador, MJ (author)
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Stamenkovic, B (author)
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Stankovic, A (author)
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Selmi, CF (author)
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De Santis, M (author)
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Tikly, M (author)
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Denisov, LN (author)
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Herrick, A (author)
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Muller-Ladner, U (author)
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Frerix, M (author)
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Tarner, I (author)
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Scorza, R (author)
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Puppo, F (author)
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Engelhart, M (author)
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Strauss, G (author)
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Nielsen, H (author)
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Damgaard, K (author)
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Szucs, G (author)
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Mendoza, AZ (author)
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de la Puente, C (author)
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Giraldo, WAS (author)
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Midtvedt, O (author)
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Reiseter, S (author)
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Garen, T (author)
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Launay, D (author)
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Valesini, G (author)
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Ionescu, RM (author)
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Groseanu, L (author)
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Opris, D (author)
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Cornateanu, RS (author)
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Ionitescu, R (author)
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Gherghe, AM (author)
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Soare, A (author)
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Gorga, M (author)
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Bojinca, M (author)
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Milicescu, M (author)
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Sunderkotter, C (author)
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Kuhn, A (author)
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Sandorfi, N (author)
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Schett, G (author)
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Beyer, C (author)
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Meroni, P (author)
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Ingegnoli, F (author)
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Mouthon, L (author)
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De Keyser, F (author)
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Melsens, K (author)
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Cantatore, FP (author)
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Corrado, A (author)
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Iversen, L (author)
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von Muhlen, CA (author)
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Bohn, JM (author)
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Lonzetti, LS (author)
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- Eyerich, K (author)
- Karolinska Institutet
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Hein, R (author)
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Knott, E (author)
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Wiland, P (author)
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Szmyrka-Kaczmarek, M (author)
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Sokolik, R (author)
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Morgiel, E (author)
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Madej, M (author)
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Houssiau, FA (author)
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Krummel-Lorenz, B (author)
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Saar, P (author)
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Aringer, M (author)
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Gunther, C (author)
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Westhovens, R (author)
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Lenaerts, J (author)
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Anic, B (author)
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Baresic, M (author)
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Mayer, M (author)
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Uprus, M (author)
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Otsa, K (author)
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Granel, B (author)
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Muller, CD (author)
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Radominski, SC (author)
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Azevedo, VF (author)
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Jimenez, S (author)
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Busquets, J (author)
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Agachi, S (author)
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Groppa, L (author)
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Chiaburu, L (author)
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Russu, E (author)
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Popa, S (author)
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Zenone, T (author)
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Pileckyte, M (author)
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Mathieu, A (author)
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Vacca, A (author)
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Sampaio-Barros, PD (author)
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Yoshinari, NH (author)
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Marangoni, RG (author)
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Martin, P (author)
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Fuocco, L (author)
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Stebbings, S (author)
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Highton, J (author)
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Chapman, P (author)
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O'Donnell, J (author)
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Stamp, L (author)
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Doube, A (author)
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Solanki, K (author)
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Veale, D (author)
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O'Rourke, M (author)
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Loyo, E (author)
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Li, MT (author)
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Mohamed, WAAA (author)
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Amoroso, A (author)
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Gigante, A (author)
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Oksel, F (author)
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Yargucu, F (author)
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Tanaseanu, CM (author)
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Popescu, M (author)
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Dumitrascu, A (author)
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Tiglea, I (author)
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Foti, R (author)
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Chirieac, R (author)
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Furst, D (author)
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Villiger, P (author)
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Adler, S (author)
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van Laar, J (author)
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Kayser, C (author)
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Fathi, N (author)
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Hassanien, M (author)
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Lefebvre, PGD (author)
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Rubio, SR (author)
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Exposito, MV (author)
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Chatelus, E (author)
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Sibilia, J (author)
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Gottenberg, JE (author)
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Chifflot, H (author)
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Litinsky, I (author)
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Emery, P (author)
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Buch, M (author)
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Del Galdo, F (author)
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Venalis, A (author)
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Butrimiene, I (author)
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Venalis, P (author)
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Rugiene, R (author)
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Karpec, D (author)
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Lasky, JA (author)
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Cosentino, V (author)
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Kerzberg, E (author)
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Montoya, F (author)
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Bianchi, W (author)
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Carneiro, S (author)
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Maretti, GB (author)
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Bianchi, DV (author)
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Limonta, M (author)
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Lupi, ALBE (author)
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Lupi, E (author)
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Rosner, I (author)
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Rozenbaum, M (author)
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Slobodin, G (author)
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Boulman, N (author)
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Rimar, D (author)
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Couto, M (author)
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Kahl, S (author)
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Chen, F (author)
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McCloskey, D (author)
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Malveaux, H (author)
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Spertini, F (author)
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Ribi, C (author)
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Buss, G (author)
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Martin, T (author)
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Guffroy, A (author)
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Poindron, V (author)
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Chotchaeva, F (author)
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Mukhin, NA (author)
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Moiseev, S (author)
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(creator_code:org_t)
- 2019-04-09
- 2019
- English.
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In: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 78:7, s. 979-987
- Related links:
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http://dx.doi.org/10...
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http://kipublication...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- To assess the safety and efficacy of rituximab in systemic sclerosis (SSc) in clinical practice.MethodsWe performed a prospective study including patients with SSc from the European Scleroderma Trials and Research (EUSTAR) network treated with rituximab and matched with untreated patients with SSc. The main outcomes measures were adverse events, skin fibrosis improvement, lung fibrosis worsening and steroids use among propensity score-matched patients treated or not with rituximab.Results254 patients were treated with rituximab, in 58% for lung and in 32% for skin involvement. After a median follow-up of 2 years, about 70% of the patients had no side effect. Comparison of treated patients with 9575 propensity-score matched patients showed that patients treated with rituximab were more likely to have skin fibrosis improvement (22.7 vs 14.03 events per 100 person-years; OR: 2.79 [1.47–5.32]; p=0.002). Treated patients did not have significantly different rates of decrease in forced vital capacity (FVC)>10% (OR: 1.03 [0.55–1.94]; p=0.93) nor in carbon monoxide diffusing capacity (DLCO) decrease. Patients having received rituximab were more prone to stop or decrease steroids (OR: 2.34 [1.56–3.53], p<0.0001). Patients treated concomitantly with mycophenolate mofetil had a trend for better outcomes as compared with patients receiving rituximab alone (delta FVC: 5.22 [0.83–9.62]; p=0.019 as compared with controls vs 3 [0.66–5.35]; p=0.012).ConclusionRituximab use was associated with a good safety profile in this large SSc-cohort. Significant change was observed on skin fibrosis, but not on lung. However, the limitation is the observational design. The potential stabilisation of lung fibrosis by rituximab has to be addressed by a randomised trial.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- lung fibrosis
- rituximab
- skin fibrosis
- systemic sclerosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Elhai, M
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Boubaya, M
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Distler, O
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Smith, V
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Matucci-Cerinic, ...
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Sancho, JJ
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Truchetet, ME
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Braun-Moscovici, ...
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Iannone, F
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Novikov, PI
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Lescoat, A
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Siegert, E
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Castellvi, I
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Airo, P
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Vettori, S
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Langhe, E
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Hachulla, E
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Erler, A
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Ananieva, L
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Krusche, M
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Lopez-Longo, FJ
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Distler, JHW
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Hunzelmann, N
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Hoffmann-Vold, A ...
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Riccieri, V
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Hsu, VM
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Pozzi, MR
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Ancuta, C
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Rosato, E
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Mihai, C
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Kuwana, M
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Saketkoo, LA
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Chizzolini, C
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Hesselstrand, Ro ...
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Ullman, S
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Yavuz, S
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Rednic, S
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Caimmi, C
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Bloch-Queyrat, C
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Allanore, Y
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Guiducci, S
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Walker, UA
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Kyburz, D
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Lapadula, G
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Maurer, B
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Jordan, S
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Dobrota, R
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Becvar, R
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Sierakowsky, S
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Bielecka, OK
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Sulli, A
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Cutolo, M
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Cuomo, G
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Nicoara, I
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Kahan, A
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Vlachoyiannopoul ...
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Montecucco, CM
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Caporali, R
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Stork, J
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Inanc, M
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Carreira, PE
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Novak, S
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Czirjak, L
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Varju, C
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Kucharz, EJ
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Kotulska, A
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Kopec-Medrek, M
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Widuchowska, M
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Cozzi, F
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Rozman, B
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Mallia, C
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Coleiro, B
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Gabrielli, A
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Farge, D
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Wu, C
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Marjanovic, Z
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Faivre, H
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Hij, D
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Dhamadi, R
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Wollheim, F
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Scheja, A
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Wuttge, DM
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Andreasson, K
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Martinovic, D
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Balbir-Gurman, A
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Trotta, F
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Lo Monaco, A
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Pellerito, R
-
Mauriziano, O
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Caramaschi, P
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Morovic-Vergles, ...
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Black, C
-
Denton, C
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Damjanov, N
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Henes, J
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Santamaria, VO
-
Heitmann, S
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Krasowska, D
-
, atthias
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Hasler, P
-
Burkhardt, H
-
Himsel, A
-
Bajocchi, G
-
Da Silva, JAP
-
Salvador, MJ
-
Stamenkovic, B
-
Stankovic, A
-
Selmi, CF
-
De Santis, M
-
Tikly, M
-
Denisov, LN
-
Herrick, A
-
Muller-Ladner, U
-
Frerix, M
-
Tarner, I
-
Scorza, R
-
Puppo, F
-
Engelhart, M
-
Strauss, G
-
Nielsen, H
-
Damgaard, K
-
Szucs, G
-
Mendoza, AZ
-
de la Puente, C
-
Giraldo, WAS
-
Midtvedt, O
-
Reiseter, S
-
Garen, T
-
Launay, D
-
Valesini, G
-
Ionescu, RM
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Groseanu, L
-
Opris, D
-
Cornateanu, RS
-
Ionitescu, R
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Gherghe, AM
-
Soare, A
-
Gorga, M
-
Bojinca, M
-
Milicescu, M
-
Sunderkotter, C
-
Kuhn, A
-
Sandorfi, N
-
Schett, G
-
Beyer, C
-
Meroni, P
-
Ingegnoli, F
-
Mouthon, L
-
De Keyser, F
-
Melsens, K
-
Cantatore, FP
-
Corrado, A
-
Iversen, L
-
von Muhlen, CA
-
Bohn, JM
-
Lonzetti, LS
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Eyerich, K
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Hein, R
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Knott, E
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Wiland, P
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Szmyrka-Kaczmare ...
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Sokolik, R
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Morgiel, E
-
Madej, M
-
Houssiau, FA
-
Krummel-Lorenz, ...
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Saar, P
-
Aringer, M
-
Gunther, C
-
Westhovens, R
-
Lenaerts, J
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Anic, B
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Baresic, M
-
Mayer, M
-
Uprus, M
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Otsa, K
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Granel, B
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Muller, CD
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Radominski, SC
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Azevedo, VF
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Jimenez, S
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Busquets, J
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Agachi, S
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Groppa, L
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Chiaburu, L
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Russu, E
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Popa, S
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Zenone, T
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Pileckyte, M
-
Mathieu, A
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Vacca, A
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Sampaio-Barros, ...
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Yoshinari, NH
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Marangoni, RG
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Martin, P
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Fuocco, L
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Stebbings, S
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Highton, J
-
Chapman, P
-
O'Donnell, J
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Stamp, L
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Doube, A
-
Solanki, K
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Veale, D
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O'Rourke, M
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Loyo, E
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Li, MT
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Mohamed, WAAA
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Amoroso, A
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Gigante, A
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Oksel, F
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Yargucu, F
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Tanaseanu, CM
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Popescu, M
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Dumitrascu, A
-
Tiglea, I
-
Foti, R
-
Chirieac, R
-
Furst, D
-
Villiger, P
-
Adler, S
-
van Laar, J
-
Kayser, C
-
Fathi, N
-
Hassanien, M
-
Lefebvre, PGD
-
Rubio, SR
-
Exposito, MV
-
Chatelus, E
-
Sibilia, J
-
Gottenberg, JE
-
Chifflot, H
-
Litinsky, I
-
Emery, P
-
Buch, M
-
Del Galdo, F
-
Venalis, A
-
Butrimiene, I
-
Venalis, P
-
Rugiene, R
-
Karpec, D
-
Lasky, JA
-
Cosentino, V
-
Kerzberg, E
-
Montoya, F
-
Bianchi, W
-
Carneiro, S
-
Maretti, GB
-
Bianchi, DV
-
Limonta, M
-
Lupi, ALBE
-
Lupi, E
-
Rosner, I
-
Rozenbaum, M
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Slobodin, G
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Boulman, N
-
Rimar, D
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Couto, M
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Kahl, S
-
Chen, F
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McCloskey, D
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Malveaux, H
-
Spertini, F
-
Ribi, C
-
Buss, G
-
Martin, T
-
Guffroy, A
-
Poindron, V
-
Chotchaeva, F
-
Mukhin, NA
-
Moiseev, S
-
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- MEDICAL AND HEALTH SCIENCES
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Karolinska Institutet
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