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Dynamic MAIT cell r...
Dynamic MAIT cell response with progressively enhanced innateness during acute HIV-1 infection
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- Lal, KG (author)
- Karolinska Institutet
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Kim, D (author)
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Costanzo, MC (author)
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Creegan, M (author)
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Leeansyah, E (author)
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Dias, J (author)
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Paquin-Proulx, D (author)
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Eller, LA (author)
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Schuetz, A (author)
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Phuang-ngern, Y (author)
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Krebs, SJ (author)
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Slike, BM (author)
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Kibuuka, H (author)
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Maganga, L (author)
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Nitayaphan, S (author)
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Kosgei, J (author)
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Sacdalan, C (author)
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Ananworanich, J (author)
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Bolton, DL (author)
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Michael, NL (author)
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Shacklett, BL (author)
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Robb, ML (author)
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Eller, MA (author)
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- Sandberg, JK (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-01-14
- 2020
- English.
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 272-
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Abstract
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- Mucosa-associated invariant T (MAIT) cell loss in chronic HIV-1 infection is a significant insult to antimicrobial immune defenses. Here we investigate the response of MAIT cells during acute HIV-1 infection utilizing the RV217 cohort with paired longitudinal pre- and post-infection samples. MAIT cells are activated and expand in blood and mucosa coincident with peak HIV-1 viremia, in a manner associated with emerging microbial translocation. This is followed by a phase with elevated function as viral replication is controlled to a set-point level, and later by their functional decline at the onset of chronic infection. Interestingly, enhanced innate-like pathways and characteristics develop progressively in MAIT cells during infection, in parallel with TCR repertoire alterations. These findings delineate the dynamic MAIT cell response to acute HIV-1 infection, and show how the MAIT compartment initially responds and expands with enhanced function, followed by progressive reprogramming away from TCR-dependent antibacterial responses towards innate-like functionality.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Lal, KG
-
Kim, D
-
Costanzo, MC
-
Creegan, M
-
Leeansyah, E
-
Dias, J
-
show more...
-
Paquin-Proulx, D
-
Eller, LA
-
Schuetz, A
-
Phuang-ngern, Y
-
Krebs, SJ
-
Slike, BM
-
Kibuuka, H
-
Maganga, L
-
Nitayaphan, S
-
Kosgei, J
-
Sacdalan, C
-
Ananworanich, J
-
Bolton, DL
-
Michael, NL
-
Shacklett, BL
-
Robb, ML
-
Eller, MA
-
Sandberg, JK
-
show less...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet