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- Belibasakis, GNKarolinska Institutet (författare)
Microbial Community-Driven Etiopathogenesis of Peri-Implantitis
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
- 2020-08-12
- SAGE Publications,2021
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- LIBRIS-ID:oai:prod.swepub.kib.ki.se:144417533
- http://kipublications.ki.se/Default.aspx?queryparsed=id:144417533URI
- https://doi.org/10.1177/0022034520949851DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- Osseointegrated dental implants are a revolutionary tool in the armament of reconstructive dentistry, employed to replace missing teeth and restore masticatory, occlusal, and esthetic functions. Like natural teeth, the orally exposed part of dental implants offers a pristine nonshedding surface for salivary pellicle-mediated microbial adhesion and biofilm formation. In early colonization stages, these bacterial communities closely resemble those of healthy periodontal sites, with lower diversity. Because the peri-implant tissues are more susceptible to endogenous oral infections, understanding of the ecological triggers that underpin the microbial pathogenesis of peri-implantitis is central to developing improved prevention, diagnosis, and therapeutic strategies. The advent of next-generation sequencing (NGS) technologies, notably applied to 16S ribosomal RNA gene amplicons, has enabled the comprehensive taxonomic characterization of peri-implant bacterial communities in health and disease, revealing a differentially abundant microbiota between these 2 states, or with periodontitis. With that, the peri-implant niche is highlighted as a distinct ecosystem that shapes its individual resident microbial community. Shifts from health to disease include an increase in diversity and a gradual depletion of commensals, along with an enrichment of classical and emerging periodontal pathogens. Metatranscriptomic profiling revealed similarities in the virulence characteristics of microbial communities from peri-implantitis and periodontitis, nonetheless with some distinctive pathways and interbacterial networks. Deeper functional assessment of the physiology and virulence of the well-characterized microbial communities of the peri-implant niche will elucidate further the etiopathogenic mechanisms and drivers of the disease.
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Manoil, DKarolinska Institutet (författare)
- Karolinska Institutet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of dental research: SAGE Publications100:1, s. 21-281544-05910022-0345
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- Journal of dental research (Sök värdpublikationen i LIBRIS)
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