onr:"swepub:oai:prod.swepub.kib.ki.se:145279793"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02977naa a2200349 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:145279793 | |
| 003 | SwePub | |
| 008 | 240701s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1452797932 URI |
| 024 | 7 | a https://doi.org/10.3390/ijms212286032 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Han, JMu Karolinska Institutet4 aut |
| 245 | 1 0 | a Underestimated Peripheral Effects Following Pharmacological and Conditional Genetic Microglial Depletion |
| 264 | c 2020-11-15 | |
| 264 | 1 | b MDPI AG,c 2020 |
| 520 | a Microglia, predominant parenchymal resident macrophages in the central nervous system (CNS), are crucial players in neurodevelopment and CNS homeostasis. In disease conditions, pro-inflammatory microglia predominate over their regulatory counterparts, and are thus a potential immunotherapeutic target. It has been well documented that microglia can be effectively depleted using both conditional genetic Cx3cr1Cre-diphtheria toxin receptor (DTR)/diphtheria toxin subunit A (DTA) animal models and pharmacological colony-stimulating factor 1 receptor (CSF1R) inhibitors. Recent advances using these approaches have expanded our knowledge of the multitude of tasks conducted by microglia in both homeostasis and diseases. Importantly, experimental microglial depletion has been proven to exert neuroprotective effects in an increasing number of disease models, mostly explained by reduced neuroinflammation. However, the comprehensive effects of additional targets such as circulating monocytes and peripheral tissue macrophages during microglial depletion periods have not been investigated widely, and for those studies addressing the issue the conclusions are mixed. In this study, we demonstrate that experimental microglial depletion using both Cx3cr1CreER/+Rosa26DTA/+ mice and different doses of CSF1R inhibitor PLX3397 exert crucial influences on circulating monocytes and peripheral tissue macrophages. Our results suggest that effects on peripheral immunity should be considered both in interpretation of microglial depletion studies, and especially in the potential translation of microglial depletion and replacement therapies. | |
| 700 | 1 | a Fan, YS4 aut |
| 700 | 1 | a Zhou, K4 aut |
| 700 | 1 | a Zhu, KYu Karolinska Institutet4 aut |
| 700 | 1 | a Blomgren, Ku Karolinska Institutet4 aut |
| 700 | 1 | a Lund, Hu Karolinska Institutet4 aut |
| 700 | 1 | a Zhang, XM4 aut |
| 700 | 1 | a Harris, RAu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t International journal of molecular sciencesd : MDPI AGg 21:22q 21:22x 1422-0067 |
| 856 | 4 | u https://www.mdpi.com/1422-0067/21/22/8603/pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145279793 |
| 856 | 4 8 | u https://doi.org/10.3390/ijms21228603 |
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