Search: onr:"swepub:oai:prod.swepub.kib.ki.se:145313049" >
Genetic predisposit...
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Steinthorsdottir, VdeCODE Genetics
(author)
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-11-25
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Springer Science and Business Media LLC,2020
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:145313049
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http://kipublications.ki.se/Default.aspx?queryparsed=id:145313049URI
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https://doi.org/10.1038/s41467-020-19733-6DOI
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https://lup.lub.lu.se/record/a6b6540a-6095-432b-9f52-8ae1ba020ef3URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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McGinnis, R
(author)
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Williams, NO
(author)
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Stefansdottir, L
(author)
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Thorleifsson, G
(author)
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Shooter, SKarolinska Institutet
(author)
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Fadista, JoaoLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Danish Serum Institute, Copenhagen(Swepub:lu)med-jft
(author)
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Sigurdsson, JKKarolinska Institutet
(author)
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Auro, KM
(author)
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Berezina, G
(author)
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Borges, MC
(author)
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Bumpstead, S
(author)
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Bybjerg-Grauholm, J
(author)
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Colgiu, I
(author)
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Dolby, VA
(author)
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Dudbridge, F
(author)
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Engel, SM
(author)
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Franklin, CS
(author)
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Frigge, MLUniversity of Nottingham
(author)
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Frisbaek, Y
(author)
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Geirsson, RT
(author)
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Geller, F
(author)
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Gretarsdottir, S
(author)
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Gudbjartsson, DF
(author)
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Harmon, Q
(author)
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Hougaard, DM
(author)
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Hegay, T
(author)
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Helgadottir, A
(author)
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Hjartardottir, S
(author)
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Jaaskelainen, T
(author)
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Johannsdottir, H
(author)
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Jonsdottir, I
(author)
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Juliusdottir, T
(author)
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Kalsheker, N
(author)
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Kasimov, A
(author)
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Kemp, JP
(author)
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Kivinen, K
(author)
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Klungsoyr, K
(author)
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Lee, WK
(author)
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Melbye, M
(author)
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Miedzybrodska, Z
(author)
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Moffett, A
(author)
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Najmutdinova, D
(author)
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Nishanova, F
(author)
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Olafsdottir, T
(author)
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Perola, M
(author)
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Pipkin, FB
(author)
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Poston, L
(author)
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Prescott, G
(author)
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Saevarsdottir, SKarolinska Institutet
(author)
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Salimbayeva, D
(author)
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Scaife, PJ
(author)
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Skotte, L
(author)
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Staines-Urias, E
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Stefansson, OA
(author)
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Sorensen, KM
(author)
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Thomsen, LCV
(author)
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Tragante, V
(author)
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Trogstad, L
(author)
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Simpson, NAB
(author)
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Laivuori, H
(author)
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Morgan, L
(author)
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Aripova, T
(author)
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Casas, JP
(author)
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Dominiczak, AF
(author)
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Walker, JJ
(author)
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Thorsteinsdottir, U
(author)
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Iversen, AC
(author)
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Feenstra, B
(author)
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Lawlor, DA
(author)
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Boyd, HA
(author)
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Magnus, P
(author)
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Laivuori, H
(author)
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Zakhidova, N
(author)
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Svyatova, G
(author)
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Stefansson, K
(author)
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Morgan, L
(author)
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Laivuori, H
(author)
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Heinonen, S
(author)
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Kajantie, E
(author)
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Kere, JKarolinska Institutet
(author)
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Kivinen, K
(author)
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Pouta, A
(author)
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Morgan, L
(author)
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Pipkin, FB
(author)
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Kalsheker, N
(author)
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Walker, JJ
(author)
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Macphail, S
(author)
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Kilby, M
(author)
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Habiba, M
(author)
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Williamson, C
(author)
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O'Shaughnessy, K
(author)
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O'Brien, S
(author)
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Cameron, A
(author)
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Redman, CWG
(author)
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Farrall, M
(author)
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Caulfield, M
(author)
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Dominiczak, AF
(author)
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Karolinska InstitutetdeCODE Genetics
(creator_code:org_t)
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In:Nature communications: Springer Science and Business Media LLC11:1, s. 5976-2041-1723
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- By the author/editor
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Steinthorsdottir ...
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McGinnis, R
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Williams, NO
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Stefansdottir, L
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Thorleifsson, G
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Shooter, S
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show more...
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Fadista, Joao
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Sigurdsson, JK
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Auro, KM
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Berezina, G
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Borges, MC
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Bumpstead, S
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Bybjerg-Grauholm ...
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Colgiu, I
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Dolby, VA
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Dudbridge, F
-
Engel, SM
-
Franklin, CS
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Frigge, ML
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Frisbaek, Y
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Geirsson, RT
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Geller, F
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Gretarsdottir, S
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Gudbjartsson, DF
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Harmon, Q
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Hougaard, DM
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Hegay, T
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Helgadottir, A
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Hjartardottir, S
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Jaaskelainen, T
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Johannsdottir, H
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Jonsdottir, I
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Juliusdottir, T
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Kalsheker, N
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Kasimov, A
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Kemp, JP
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Kivinen, K
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Klungsoyr, K
-
Lee, WK
-
Melbye, M
-
Miedzybrodska, Z
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Moffett, A
-
Najmutdinova, D
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Nishanova, F
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Olafsdottir, T
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Perola, M
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Pipkin, FB
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Poston, L
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Prescott, G
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Saevarsdottir, S
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Salimbayeva, D
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Scaife, PJ
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Skotte, L
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Staines-Urias, E
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Stefansson, OA
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Sorensen, KM
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Thomsen, LCV
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Tragante, V
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Trogstad, L
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Simpson, NAB
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Laivuori, H
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Morgan, L
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Aripova, T
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Casas, JP
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Dominiczak, AF
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Walker, JJ
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Thorsteinsdottir ...
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Iversen, AC
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Feenstra, B
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Lawlor, DA
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Boyd, HA
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Magnus, P
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Zakhidova, N
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Svyatova, G
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Stefansson, K
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Heinonen, S
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Kajantie, E
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Kere, J
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Pouta, A
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Macphail, S
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Kilby, M
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Habiba, M
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Williamson, C
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O'Shaughnessy, K
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O'Brien, S
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Cameron, A
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Redman, CWG
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Farrall, M
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Caulfield, M
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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Nature communica ...
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Karolinska Institutet
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Lund University