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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02838naa a2200349 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:145814894 | |
| 003 | SwePub | |
| 008 | 240701s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1458148942 URI |
| 024 | 7 | a https://doi.org/10.1159/0005122872 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Butcher, L4 aut |
| 245 | 1 0 | a Higher sRAGE Levels Predict Mortality in Frail Older Adults with Cardiovascular Disease |
| 264 | c 2021-01-21 | |
| 264 | 1 | b S. Karger AG,c 2021 |
| 520 | a <b><i>Introduction:</i></b> The evidence that blood levels of the soluble receptor for advanced glycation end products (sRAGE) predict mortality in people with cardiovascular diseases (CVD) is inconsistent. To clarify this matter, we investigated if frailty status influences this association. <b><i>Methods:</i></b> We analysed data of 1,016 individuals (median age, 75 years) from 3 population-based European cohorts, enrolled in the FRAILOMIC project. Participants were stratified by history of CVD and frailty status. Mortality was recorded during 8 years of follow-up. <b><i>Results:</i></b> In adjusted Cox regression models, baseline serum sRAGE was positively associated with an increased risk of mortality in participants with CVD (HR 1.64, 95% CI 1.09–2.49, <i>p</i> = 0.019) but not in non-CVD. Within the CVD group, the risk of death was markedly enhanced in the frail subgroup (CVD-F, HR 1.97, 95% CI 1.18–3.29, <i>p</i> = 0.009), compared to the non-frail subgroup (CVD-NF, HR 1.50, 95% CI 0.71–3.15, <i>p</i> = 0.287). Kaplan-Meier analysis showed that the median survival time of CVD-F with high sRAGE (>1,554 pg/mL) was 2.9 years shorter than that of CVD-F with low sRAGE, whereas no survival difference was seen for CVD-NF. Area under the ROC curve analysis demonstrated that for CVD-F, addition of sRAGE to the prediction model increased its prognostic value. <b><i>Conclusions:</i></b> Frailty status influences the relationship between sRAGE and mortality in older adults with CVD. sRAGE could be used as a prognostic marker of mortality for these individuals, particularly if they are also frail. | |
| 700 | 1 | a Carnicero, JA4 aut |
| 700 | 1 | a Peres, K4 aut |
| 700 | 1 | a Colpo, M4 aut |
| 700 | 1 | a Cabrero, DG4 aut |
| 700 | 1 | a Dartigues, JF4 aut |
| 700 | 1 | a Bandinelli, S4 aut |
| 700 | 1 | a Garcia-Garcia, FJ4 aut |
| 700 | 1 | a Rodriguez-Manas, L4 aut |
| 700 | 1 | a Erusalimsky, JD4 aut |
| 773 | 0 | t Gerontologyd : S. Karger AGg 67:2, s. 202-210q 67:2<202-210x 1423-0003x 0304-324X |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:145814894 |
| 856 | 4 8 | u https://doi.org/10.1159/000512287 |
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