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Preexisting autoant...
Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1
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Bastard, P (author)
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Orlova, E (author)
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Sozaeva, L (author)
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Levy, R (author)
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James, A (author)
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Schmitt, MM (author)
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Ochoa, S (author)
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Kareva, M (author)
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Rodina, Y (author)
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Gervais, A (author)
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Le Voyer, T (author)
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Rosain, J (author)
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Philippot, Q (author)
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Neehus, AL (author)
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Shaw, E (author)
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Migaud, M (author)
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Bizien, L (author)
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Ekwall, O (author)
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Berg, S (author)
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Beccuti, G (author)
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Ghizzoni, L (author)
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Thiriez, G (author)
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Pavot, A (author)
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Goujard, C (author)
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Fremond, ML (author)
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Carter, E (author)
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Rothenbuhler, A (author)
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Linglart, A (author)
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Mignot, B (author)
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Comte, A (author)
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Cheikh, N (author)
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Hermine, O (author)
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Breivik, L (author)
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Husebye, ES (author)
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Humbert, S (author)
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Rohrlich, P (author)
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Coaquette, A (author)
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Vuoto, F (author)
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Faure, K (author)
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Mahlaoui, N (author)
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Kotnik, P (author)
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Battelino, T (author)
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Podkrajsek, KT (author)
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Kisand, K (author)
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Ferre, EMN (author)
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DiMaggio, T (author)
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Rosen, LB (author)
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Burbelo, PD (author)
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McIntyre, M (author)
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Kann, NY (author)
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Shcherbina, A (author)
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Pavlova, M (author)
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Kolodkina, A (author)
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Holland, SM (author)
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Zhang, SY (author)
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Crow, YJ (author)
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Notarangelo, LD (author)
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Su, HC (author)
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Abel, L (author)
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Anderson, MS (author)
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Jouanguy, E (author)
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Neven, B (author)
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Puel, A (author)
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Casanova, JL (author)
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Lionakis, MS (author)
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- 2021-04-23
- 2021
- English.
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 218:7
- Related links:
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https://rupress.org/...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-α subtypes and/or IFN-ω; one had anti–IFN-β and another anti–IFN-ε, but none had anti–IFN-κ. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age.
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Bastard, P
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Orlova, E
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Sozaeva, L
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Levy, R
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James, A
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Schmitt, MM
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show more...
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Ochoa, S
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Kareva, M
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Rodina, Y
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Gervais, A
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Le Voyer, T
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Rosain, J
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Philippot, Q
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Neehus, AL
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Shaw, E
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Migaud, M
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Bizien, L
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Ekwall, O
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Berg, S
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Beccuti, G
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Ghizzoni, L
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Thiriez, G
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Pavot, A
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Goujard, C
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Fremond, ML
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Carter, E
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Rothenbuhler, A
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Linglart, A
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Mignot, B
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Comte, A
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Cheikh, N
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Hermine, O
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Breivik, L
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Husebye, ES
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Humbert, S
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Rohrlich, P
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Coaquette, A
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Vuoto, F
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Faure, K
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Mahlaoui, N
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Kotnik, P
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Battelino, T
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Podkrajsek, KT
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Kisand, K
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Ferre, EMN
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DiMaggio, T
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Rosen, LB
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Burbelo, PD
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McIntyre, M
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Kann, NY
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Shcherbina, A
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Pavlova, M
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Kolodkina, A
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Holland, SM
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Zhang, SY
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Crow, YJ
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Notarangelo, LD
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Su, HC
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Abel, L
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Anderson, MS
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Jouanguy, E
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Neven, B
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Puel, A
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Casanova, JL
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Lionakis, MS
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show less...
- Articles in the publication
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The Journal of e ...
- By the university
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Karolinska Institutet