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Inhibition of colon...
Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-04-02
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Springer Science and Business Media LLC,2022
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:149259241
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149259241URI
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https://doi.org/10.1007/s00018-022-04225-1DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Microglia are specialized dynamic immune cells in the central nervous system (CNS) that plays a crucial role in brain homeostasis and in disease states. Persistent neuroinflammation is considered a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson's disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS) and primary progressive multiple sclerosis (MS). Colony stimulating factor 1-receptor (CSF-1R) is predominantly expressed on microglia and its expression is significantly increased in neurodegenerative diseases. Cumulative findings have indicated that CSF-1R inhibitors can have beneficial effects in preclinical neurodegenerative disease models. Research using CSF-1R inhibitors has now been extended into non-human primates and humans. This review article summarizes the most recent advances using CSF-1R inhibitors in different neurodegenerative conditions including AD, PD, HD, ALS and MS. Potential challenges for translating these findings into clinical practice are presented.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Chitu, V
(författare)
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Stanley, ER
(författare)
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Wszolek, ZK
(författare)
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Karrenbauer, VDKarolinska Institutet
(författare)
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Harris, RAKarolinska Institutet
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Cellular and molecular life sciences : CMLS: Springer Science and Business Media LLC79:4, s. 219-1420-90711420-682X
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