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Subtype-Specific Su...
Subtype-Specific Surface Proteins on Adipose Tissue Macrophages and Their Association to Obesity-Induced Insulin Resistance
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Strand, K (author)
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Stiglund, N (author)
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Haugstoyl, ME (author)
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Kamyab, Z (author)
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Langhelle, V (author)
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Dyer, L (author)
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Busch, C (author)
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Cornillet, M (author)
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Hjellestad, ID (author)
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Nielsen, HJ (author)
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Njolstad, PR (author)
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Mellgren, G (author)
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- Bjorkstrom, NK (author)
- Karolinska Institutet
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Ferno, J (author)
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(creator_code:org_t)
- 2022-04-11
- 2022
- English.
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In: Frontiers in endocrinology. - : Frontiers Media SA. - 1664-2392. ; 13, s. 856530-
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https://doi.org/10.3...
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Abstract
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- A chronic low-grade inflammation, originating in the adipose tissue, is considered a driver of obesity-associated insulin resistance. Macrophage composition in white adipose tissue is believed to contribute to the pathogenesis of metabolic diseases, but a detailed characterization of pro- and anti-inflammatory adipose tissue macrophages (ATMs) in human obesity and how they are distributed in visceral- and subcutaneous adipose depots is lacking. In this study, we performed a surface proteome screening of pro- and anti-inflammatory ATMs in both subcutaneous- (SAT) and visceral adipose tissue (VAT) and evaluated their relationship with systemic insulin resistance. From the proteomics screen we found novel surface proteins specific to M1-like- and M2-like macrophages, and we identified depot-specific immunophenotypes in SAT and VAT. Furthermore, we found that insulin resistance, assessed by HOMA-IR, was positively associated with a relative increase in pro-inflammatory M1-like macrophages in both SAT and VAT.
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Strand, K
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Stiglund, N
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Haugstoyl, ME
-
Kamyab, Z
-
Langhelle, V
-
Dyer, L
-
show more...
-
Busch, C
-
Cornillet, M
-
Hjellestad, ID
-
Nielsen, HJ
-
Njolstad, PR
-
Mellgren, G
-
Bjorkstrom, NK
-
Ferno, J
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show less...
- Articles in the publication
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Frontiers in end ...
- By the university
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Karolinska Institutet