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Vascular Tissue Spe...
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Neiburga, KD
(författare)
Vascular Tissue Specific miRNA Profiles Reveal Novel Correlations with Risk Factors in Coronary Artery Disease
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:150279787
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http://kipublications.ki.se/Default.aspx?queryparsed=id:150279787URI
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https://doi.org/10.3390/biom11111683DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Non-coding RNAs have already been linked to CVD development and progression. While microRNAs (miRs) have been well studied in blood samples, there is little data on tissue-specific miRs in cardiovascular relevant tissues and their relation to cardiovascular risk factors. Tissue-specific miRs derived from Arteria mammaria interna (IMA) from 192 coronary artery disease (CAD) patients undergoing coronary artery bypass grafting (CABG) were analyzed. The aims of the study were 1) to establish a reference atlas which can be utilized for identification of novel diagnostic biomarkers and potential therapeutic targets, and 2) to relate these miRs to cardiovascular risk factors. Overall, 393 individual miRs showed sufficient expression levels and passed quality control for further analysis. We identified 17 miRs–miR-10b-3p, miR-10-5p, miR-17-3p, miR-21-5p, miR-151a-5p, miR-181a-5p, miR-185-5p, miR-194-5p, miR-199a-3p, miR-199b-3p, miR-212-3p, miR-363-3p, miR-548d-5p, miR-744-5p, miR-3117-3p, miR-5683 and miR-5701–significantly correlated with cardiovascular risk factors (correlation coefficient >0.2 in both directions, p-value (p < 0.006, false discovery rate (FDR) <0.05). Of particular interest, miR-5701 was positively correlated with hypertension, hypercholesterolemia, and diabetes. In addition, we found that miR-629-5p and miR-98-5p were significantly correlated with acute myocardial infarction. We provide a first atlas of miR profiles in IMA samples from CAD patients. In perspective, these miRs might play an important role in improved risk assessment, mechanistic disease understanding and local therapy of CAD.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Vilne, B
(författare)
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Bauer, S
(författare)
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Bongiovanni, D
(författare)
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Ziegler, T
(författare)
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Lachmann, M
(författare)
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Wengert, S
(författare)
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Hawe, JS
(författare)
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Guldener, U
(författare)
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Westerlund, AM
(författare)
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Li, L
(författare)
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Pang, SC
(författare)
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Yang, CH
(författare)
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Saar, K
(författare)
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Huebner, N
(författare)
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Maegdefessel, LKarolinska Institutet
(författare)
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Lange, R
(författare)
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Krane, M
(författare)
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Schunkert, H
(författare)
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von Scheidt, M
(författare)
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Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Biomolecules: MDPI AG11:112218-273X
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Neiburga, KD
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Vilne, B
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Bauer, S
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Bongiovanni, D
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Ziegler, T
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Lachmann, M
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visa fler...
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Wengert, S
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Hawe, JS
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Guldener, U
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Westerlund, AM
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Li, L
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Pang, SC
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Yang, CH
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Saar, K
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Huebner, N
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Maegdefessel, L
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Lange, R
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Krane, M
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Schunkert, H
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von Scheidt, M
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visa färre...
- Artiklar i publikationen
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Biomolecules
- Av lärosätet
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Karolinska Institutet