Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:1956247" >
Amelotin--a Novel S...
Amelotin--a Novel Secreted, Ameloblast-specific Protein
-
Iwasaki, K (författare)
-
Bajenova, E (författare)
-
Somogyi-Ganss, E (författare)
-
visa fler...
-
Miller, M (författare)
-
Nguyen, V (författare)
-
Nourkeyhani, H (författare)
-
Gao, Y (författare)
-
Wendel, M (författare)
-
Ganss, B (författare)
-
visa färre...
- 2016-12-15
- 2005
- Engelska.
-
Ingår i: Journal of dental research. - : SAGE Publications. - 0022-0345 .- 1544-0591. ; 84:12, s. 1127-1132
- Relaterad länk:
-
http://kipublication...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- We aimed to analyze the differential gene expression in various murine dental tissues, expecting to find novel factors that are involved in tooth formation. We here describe the identification of a novel ameloblast-specific gene, amelotin (AMTN), by differential display polymerase chain-reaction (DD-PCR) analysis of microdissected ameloblasts, odontoblasts, dental pulp, and alveolar bone cells of 10-day-old mouse incisors. The conceptually translated protein sequence was unique and showed significant homology only with its human orthologue. The amelotin genes from mouse and human displayed a similar exon-intron structure and were expressed from loci on chromosomes 5 and 4, respectively, which have been associated with various forms of amelogenesis imperfecta. Expression of amelotin mRNA was restricted to maturation-stage ameloblasts in developing murine molars and incisors. Amelotin protein was efficiently secreted from transfected cells in culture. Taken together, our findings suggest that amelotin is a novel factor produced by ameloblasts that plays a critical role in the formation of dental enamel.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas