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Oxygen-conserving e...
Oxygen-conserving effects of apnea in exercising men
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- Lindholm, P (författare)
- Karolinska Institutet
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- Sundblad, P (författare)
- Karolinska Institutet
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- Linnarsson, D (författare)
- Karolinska Institutet
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(creator_code:org_t)
- American Physiological Society, 1999
- 1999
- Engelska.
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Ingår i: Journal of applied physiology (Bethesda, Md. : 1985). - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 87:6, s. 2122-2127
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Abstract
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- We sought to determine whether apnea-induced cardiovascular responses resulted in a biologically significant temporary O2 conservation during exercise. Nine healthy men performing steady-state leg exercise carried out repeated apnea (A) and rebreathing (R) maneuvers starting with residual volume +3.5 liters of air. Heart rate (HR), mean arterial pressure (MAP), and arterial O2 saturation (SaO2 ; pulse oximetry) were recorded continuously. Responses (ΔHR, ΔMAP) were determined as differences between HR and MAP at baseline before the maneuver and the average of values recorded between 25 and 30 s into each maneuver. The rate of O2 desaturation (ΔSaO2 /Δ t) was determined during the same time interval. During apnea, ΔSaO2/Δ t had a significant negative correlation to the amplitudes of ΔHR and ΔMAP ( r 2 = 0.88, P < 0.001); i.e., individuals with the most prominent cardiovascular responses had the slowest ΔSaO2 /Δ t. ΔHR and ΔMAP were much larger during A (−44 ± 8 beats/min, +49 ± 4 mmHg, respectively) than during R maneuver (+3 ± 3 beats/min, +30 ± 5 mmHg, respectively). ΔSaO2 /Δ t during A and R maneuvers was −1.1 ± 0.1 and −2.2 ± 0.2% units/s, respectively, and nadir SaO2 values were 58 ± 4 and 42 ± 3% units, respectively. We conclude that bradycardia and hypertension during apnea are associated with a significant temporary O2 conservation and that respiratory arrest, rather than the associated hypoxia, is essential for these responses.
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