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Hyperthermic intrap...
Hyperthermic intraperitoneal chemotherapy (HIPEC) as another treatment modality for desmoplastic round cell tumour patients: first paediatric experience from UK
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- Sjoberg Bexelius, T (författare)
- Karolinska Institutet
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Chisholm, JC (författare)
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Okoye, B (författare)
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Cecil, T (författare)
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Angelini, P (författare)
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Dayal, S (författare)
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(creator_code:org_t)
- 2021-01-28
- 2021
- Engelska.
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Ingår i: BMJ case reports. - : BMJ. - 1757-790X. ; 14:1
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- We present the first young paediatric patient with desmoplastic small round cell tumour (DSRCT) treated in UK with hyperthermic intraperitoneal chemotherapy (HIPEC). A 7-year-old girl was diagnosed with abdominal DSRCT with peritoneal and liver metastases. After six cycles of chemotherapy she obtained a partial response, including almost complete resolution of the two liver metastases. It was decided to pursue cytoreductive surgery (CRS) combined with HIPEC, a procedure commonly performed in adults, but seldom in a child. The surgery was macroscopically complete and the HIPEC uncomplicated. She continued treatment without delays, including whole abdomino-pelvic radiotherapy and maintenance chemotherapy (cyclophosphamide/vinorelbine for 12 months). She is currently in complete remission 4 months after end of treatment and 26 months after diagnosis. HIPEC was made possible by successful collaboration between multiple teams. CRS-HIPEC proved to be safe and feasible and could be offered to other children with diagnoses of peritoneal malignancies across the UK.
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