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Randomized Trial fo...
Randomized Trial for Weight Loss Using a Digital Therapeutic Application
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Thorgeirsson, T (författare)
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Torfadottir, JE (författare)
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Egilsson, E (författare)
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Oddsson, S (författare)
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Gunnarsdottir, T (författare)
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Aspelund, T (författare)
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Olafsdottir, AS (författare)
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- Valdimarsdottir, UA (författare)
- Karolinska Institutet
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Kawachi, I (författare)
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- Adami, HO (författare)
- Karolinska Institutet
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Bjarnason, RG (författare)
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(creator_code:org_t)
- 2021-03-19
- 2022
- Engelska.
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Ingår i: Journal of diabetes science and technology. - : SAGE Publications. - 1932-2968. ; 16:5, s. 1150-1158
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Smartphones present a near-ubiquitous channel through which structured lifestyle change can reduce risk or progression of the most common noncommunicable diseases. We explored whether a digital structured lifestyle program enhances weight loss. Methods: We randomized overweight and obese participants attending a four-month lifestyle change program to either standard weekly coaching sessions (controls), or standard treatment supplemented with a digital therapeutic mobile application (intervention). Changes in body mass index after four months were the main outcome measure. Odds ratios of achieving 5% weight loss were estimated with unconditional logistic regression. Results: Of 234 eligible persons, 146 (62%) agreed to participate, were block-randomized, showed up for the baseline measures, and constituted the intention-to-treat (ITT) sample ( n = 95 intervention group, n = 51 control group). In the intervention group, 70 (74%) downloaded the mobile application and completed the program (intervention per-protocol). Significant weight loss and BMI reduction were observed for both the intention-to-treat intervention group ( P < 0.05, P = 0.01) and the per-protocol intervention group ( P < 0.0001, P < 0.0001). For the intervention per-protocol group, the odds ratio of achieving 5% weight loss, compared to not treated per-protocol, was 3.3 (95% CI 1.3-8.2), adjusting for age and weight at baseline.Attendance to weekly coaching sessions decreased by 18% during the program in the control group while it increased by 3% amongst the per-protocol group ( P = 0.004). Conclusions: These preliminary findings support the benefit of a digital therapeutic to enhance weight reduction and attendance in a structured lifestyle change program. Larger trials of longer duration are needed to confirm these findings.
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Thorgeirsson, T
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Torfadottir, JE
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Egilsson, E
-
Oddsson, S
-
Gunnarsdottir, T
-
Aspelund, T
-
visa fler...
-
Olafsdottir, AS
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Valdimarsdottir, ...
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Kawachi, I
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Adami, HO
-
Bjarnason, RG
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visa färre...
- Artiklar i publikationen
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Journal of diabe ...
- Av lärosätet
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Karolinska Institutet