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Alternative splicing of OAS1 alters the risk for severe COVID-19

Huffman, J (author)
Butler-Laporte, G (author)
Khan, A (author)
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Drivas, TG (author)
Peloso, GM (author)
Nakanishi, T (author)
Verma, A (author)
Kiryluk, K (author)
Richards, JB (author)
Zeberg, H (author)
Karolinska Institutet
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 (creator_code:org_t)
Cold Spring Harbor Laboratory, 2021
2021
English.
In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
  • Journal article (other academic/artistic)
Abstract Subject headings
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  • A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ∼75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry.

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