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Alternative splicin...
Alternative splicing of OAS1 alters the risk for severe COVID-19
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Huffman, J (author)
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Butler-Laporte, G (author)
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Khan, A (author)
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Drivas, TG (author)
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Peloso, GM (author)
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Nakanishi, T (author)
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Verma, A (author)
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Kiryluk, K (author)
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Richards, JB (author)
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- Zeberg, H (author)
- Karolinska Institutet
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(creator_code:org_t)
- Cold Spring Harbor Laboratory, 2021
- 2021
- English.
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In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
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https://www.medrxiv....
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- A locus containing OAS1/2/3 has been identified as a risk locus for severe COVID-19 among Europeans ancestry individuals, with a protective haplotype of ∼75 kilobases derived from Neanderthals. Here, we show that among several potentially causal variants at this locus, a splice variant of OAS1 occurs in people of African ancestry independently of the Neanderthal haplotype and confers protection against COVID-19 of a magnitude similar to that seen in individuals without African ancestry.
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- art (subject category)
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- By the author/editor
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Huffman, J
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Butler-Laporte, ...
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Khan, A
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Drivas, TG
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Peloso, GM
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Nakanishi, T
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show more...
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Verma, A
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Kiryluk, K
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Richards, JB
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Zeberg, H
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show less...
- Articles in the publication
- medRxiv : the pr ...
- By the university
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Karolinska Institutet