Search: onr:"swepub:oai:research.chalmers.se:2947fbe0-c4db-428f-96eb-811eddeaee37" >
Network analyses id...
Network analyses identify liver-specific targets for treating liver diseases
-
- Lee, SangWook (author)
- Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
-
- Zhang, C. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
-
- Liu, Zhengtao (author)
- KTH,Science for Life Laboratory, SciLifeLab,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
-
show more...
-
- Klevstig, Martina (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
-
- Mukhopadhyay, B. (author)
- National Institute on Alcohol Abuse and Alcoholism
-
- Bergentall, Mattias (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
-
- Cinar, R. (author)
- National Institute on Alcohol Abuse and Alcoholism
-
- Ståhlman, Marcus, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
-
- Sikanic, Natasa (author)
- KTH,Proteinvetenskap,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
-
- Park, Joshua K. (author)
- National Institute on Alcohol Abuse and Alcoholism
-
- Deshmukh, Sumit (author)
- KTH,Proteinvetenskap,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
-
- Harzandi, Azadeh M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
-
- Kuijpers, Tim (author)
- KTH,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
-
- Grötli, Morten, 1966 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology,University of Gothenburg
-
- Elsässer, Simon J. (author)
- Karolinska Institutet
-
- Piening, B. D. (author)
- Stanford University
-
- Snyder, M. (author)
- Stanford University
-
- Smith, Ulf, 1943 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
-
- Nielsen, Jens B, 1962 (author)
- KTH,Science for Life Laboratory, SciLifeLab,Chalmers tekniska högskola,Chalmers University of Technology
-
- Bäckhed, Fredrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
-
- Kunos, G. (author)
- National Institute on Alcohol Abuse and Alcoholism
-
- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
-
- Borén, Jan, 1963 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska universitetssjukhuset,Sahlgrenska University Hospital
-
- Mardinoglu, Adil, 1982 (author)
- KTH,Science for Life Laboratory, SciLifeLab,Chalmers tekniska högskola,Chalmers University of Technology
-
- Lee, Sunjae (author)
- KTH,Science for Life Laboratory, SciLifeLab
-
show less...
-
(creator_code:org_t)
- 2017-08-21
- 2017
- English.
-
In: Molecular Systems Biology. - : EMBO. - 1744-4292. ; 13:8
- Related links:
-
http://publications.... (primary) (free)
-
show more...
-
https://doi.org/10.1...
-
https://kth.diva-por... (primary) (Raw object)
-
https://doi.org/10.1...
-
https://research.cha...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://gup.ub.gu.se...
-
show less...
Abstract
Subject headings
Close
- We performed integrative network analyses to identify targets that can be used for effectively treating liver diseases with minimal side effects. We first generated co-expression networks (CNs) for 46 human tissues and liver cancer to explore the functional relationships between genes and examined the overlap between functional and physical interactions. Since increased de novo lipogenesis is a characteristic of nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC), we investigated the liver-specific genes co-expressed with fatty acid synthase (FASN). CN analyses predicted that inhibition of these liver-specific genes decreases FASN expression. Experiments in human cancer cell lines, mouse liver samples, and primary human hepatocytes validated our predictions by demonstrating functional relationships between these liver genes, and showing that their inhibition decreases cell growth and liver fat content. In conclusion, we identified liver-specific genes linked to NAFLD pathogenesis, such as pyruvate kinase liver and red blood cell (PKLR), or to HCC pathogenesis, such as PKLR, patatin-like phospholipase domain containing 3 (PNPLA3), and proprotein convertase subtilisin/kexin type 9 (PCSK9), all of which are potential targets for drug development.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- metabolism
- NAFLD
- co-regulation
- co-expression
- HCC
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Lee, SangWook
-
Zhang, C.
-
Liu, Zhengtao
-
Klevstig, Martin ...
-
Mukhopadhyay, B.
-
Bergentall, Matt ...
-
show more...
-
Cinar, R.
-
Ståhlman, Marcus ...
-
Sikanic, Natasa
-
Park, Joshua K.
-
Deshmukh, Sumit
-
Harzandi, Azadeh ...
-
Kuijpers, Tim
-
Grötli, Morten, ...
-
Elsässer, Simon ...
-
Piening, B. D.
-
Snyder, M.
-
Smith, Ulf, 1943
-
Nielsen, Jens B, ...
-
Bäckhed, Fredrik ...
-
Kunos, G.
-
Uhlén, Mathias
-
Borén, Jan, 1963
-
Mardinoglu, Adil ...
-
Lee, Sunjae
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Cell Biology
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Bioinformatics a ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Gastroenterology ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
- Articles in the publication
-
Molecular System ...
- By the university
-
Chalmers University of Technology
-
Royal Institute of Technology
-
Karolinska Institutet
-
University of Gothenburg