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Parallel Factor Ana...
Parallel Factor Analysis Enables Quantification and Identification of Highly Convolved Data-Independent-Acquired Protein Spectra
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- Buric, Filip, 1988 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Zrimec, Jan, 1981 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Zelezniak, Aleksej, 1984 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology,Science for Life Laboratory (SciLifeLab)
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
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Ingår i: Patterns. - : Elsevier BV. - 2666-3899. ; 1:9
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https://research.cha... (primary) (free)
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http://www.cell.com/...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The latest high-throughput mass spectrometry-based technologies can record virtually all molecules from complex biological samples, providing a holistic picture of proteomes in cells and tissues and enabling an evaluation of the overall status of a person's health. However, current best practices are still only scratching the surface of the wealth of available information obtained from the massive proteome datasets, and efficient novel data-driven strategies are needed. Powered by advances in GPU hardware and open-source machine-learning frameworks, we developed a data-driven approach, CANDIA, which disassembles highly complex proteomics data into the elementary molecular signatures of the proteins in biological samples. Our work provides a performant and adaptable solution that complements existing mass spectrometry techniques. As the central mathematical methods are generic, other scientific fields that are dealing with highly convolved datasets will benefit from this work.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Nyckelord
- deconvolution
- data-independent acquisition
- tensor factorization
- DSML 2: Proof-of-Concept: Data science output has been formulated, implemented, and tested for one domain/problem
- canonical decomposition
- big data
- proteomics
- PARAFAC
- mass spectrometry
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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