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A Perspective on Synthetic Biology in Drug Discovery and Development - Current Impact and Future Opportunities

David, Florian, 1981 (author)
Chalmers tekniska högskola,Chalmers University of Technology
Davis, Andrew M. (author)
AstraZeneca AB
Gossing, Michael, 1982 (author)
AstraZeneca AB
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Hayes, Martin A. (author)
AstraZeneca AB
Romero, Elvira (author)
AstraZeneca AB
Scott, Louis H. (author)
AstraZeneca AB
Wigglesworth, Mark J. (author)
AstraZeneca AB
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 (creator_code:org_t)
Elsevier BV, 2021
2021
English.
In: SLAS Discovery. - : Elsevier BV. - 2472-5552 .- 2472-5560. ; 26:5, s. 581-603
  • Research review (peer-reviewed)
Abstract Subject headings
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  • The global impact of synthetic biology has been accelerating, because of the plummeting cost of DNA synthesis, advances in genetic engineering, growing understanding of genome organization, and explosion in data science. However, much of the discipline’s application in the pharmaceutical industry remains enigmatic. In this review, we highlight recent examples of the impact of synthetic biology on target validation, assay development, hit finding, lead optimization, and chemical synthesis, through to the development of cellular therapeutics. We also highlight the availability of tools and technologies driving the discipline. Synthetic biology is certainly impacting all stages of drug discovery and development, and the recognition of the discipline’s contribution can further enhance the opportunities for the drug discovery and development value chain.

Subject headings

TEKNIK OCH TEKNOLOGIER  -- Maskinteknik -- Annan maskinteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY  -- Mechanical Engineering -- Other Mechanical Engineering (hsv//eng)
NATURVETENSKAP  -- Data- och informationsvetenskap -- Programvaruteknik (hsv//swe)
NATURAL SCIENCES  -- Computer and Information Sciences -- Software Engineering (hsv//eng)
NATURVETENSKAP  -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)

Keyword

late-stage functionalization
chassis organism
drug discovery
synthetic biology
biofoundry
CRISPR-Cas9

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