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Multiscale Characte...
Multiscale Characterization of Embryonic Long Bone Mineralization in Mice
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- Silva Barreto, Isabella (författare)
- Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Le Cann, Sophie (författare)
- Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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- Ahmed, Saima (författare)
- Imperial College of Science, Technology and Medicine,Imperial College London
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- Sotiriou, Vivien (författare)
- Imperial College of Science, Technology and Medicine,Imperial College London
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- Turunen, Mikael J. (författare)
- Itä-Suomen Yliopisto,University of Eastern Finland
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- Johansson, Ulf (författare)
- Lund University,Lunds universitet,MAX IV-laboratoriet,MAX IV Laboratory
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- Rodriguez-Fernandez, Angel (författare)
- Lund University,Lunds universitet,MAX IV-laboratoriet,MAX IV Laboratory
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- Grünewald, Tilman A. (författare)
- European Synchrotron Radiation Facility (ESRF),European Synchrotron Radiation Facility
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- Liebi, Marianne, 1984 (författare)
- Chalmers University of Technology
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- Nowlan, Niamh C. (författare)
- Imperial College of Science, Technology and Medicine,Imperial College London
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- Isaksson, Hanna (författare)
- Lund University,Lunds universitet,Institutionen för biomedicinsk teknik,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Biomedical Engineering,Departments at LTH,Faculty of Engineering, LTH
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(creator_code:org_t)
- 2020-09-24
- 2020
- Engelska.
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Ingår i: Advanced Science. - : Wiley. - 2198-3844 .- 2198-3844. ; 7:21
- Relaterad länk:
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https://research.cha... (primary) (free)
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://research.cha...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Long bone mineralization occurs through endochondral ossification, where a cartilage template mineralizes into bone-like tissue with a hierarchical organization from the whole bone-scale down to sub-nano scale. Whereas this process has been extensively studied at the larger length scales, it remains unexplored at some of the smaller length scales. In this study, the changes in morphology, composition, and structure during embryonic mineralization of murine humeri are investigated using a range of high-resolution synchrotron-based imaging techniques at several length scales. With micro- and nanometer spatial resolution, the deposition of elements and the shaping of mineral platelets are followed. Rapid mineralization of the humeri occurs over approximately four days, where mineral to matrix ratio and calcium content in the most mineralized zone reach adult values shortly before birth. Interestingly, zinc is consistently found to be localized at the sites of ongoing new mineralization. The mineral platelets in the most recently mineralized regions are thicker, longer, narrower, and less aligned compared to those further into the mineralized region. In summary, this study demonstrates a specific spatial distribution of zinc, with highest concentration where new mineral is being deposited and that the newly formed mineral platelets undergo slight reshaping and reorganization during embryonic development.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Geologi (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Geology (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Geokemi (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Geochemistry (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Multidisciplinär geovetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Geosciences, Multidisciplinary (hsv//eng)
Nyckelord
- small- and wide-angle X-ray scattering
- X-ray tomography
- bone development
- Fourier transform infra-red microspectroscopy
- X-ray fluorescence spectroscopy
- bone development
- Fourier transform infra-red microspectroscopy
- small- and wide-angle X-ray scattering
- X-ray fluorescence spectroscopy
- X-ray tomography
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Silva Barreto, I ...
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Le Cann, Sophie
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Ahmed, Saima
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Sotiriou, Vivien
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Turunen, Mikael ...
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Johansson, Ulf
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visa fler...
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Rodriguez-Fernan ...
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Grünewald, Tilma ...
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Liebi, Marianne, ...
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Nowlan, Niamh C.
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Isaksson, Hanna
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
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och Geologi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
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och Geokemi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Geovetenskap och ...
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och Multidisciplinär ...
- Artiklar i publikationen
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Advanced Science
- Av lärosätet
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Chalmers tekniska högskola
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Lunds universitet