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Voluntary Running S...
Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution
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- Pedersen, L. (author)
- Köpenhamns universitet,University of Copenhagen
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- Idorn, M. (author)
- Copenhagen University Hospital
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- Olofsson, G. H. (author)
- Copenhagen University Hospital
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- Lauenborg, B. (author)
- Köpenhamns universitet,University of Copenhagen
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- Nookaew, Intawat, 1977 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Hansen, R. H. (author)
- Amtssygehuset i Herlev
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- Johannesen, H. H. (author)
- Amtssygehuset i Herlev
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- Becker, J. C. (author)
- Universitats Klinikum Essen und Medizinische Fakultat
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- Pedersen, K. S. (author)
- Köpenhamns universitet,University of Copenhagen
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- Dethlefsen, C. (author)
- Köpenhamns universitet,University of Copenhagen
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- Nielsen, Jens B, 1962 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Gehl, J. (author)
- Copenhagen University Hospital
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- Pedersen, B. K. (author)
- Köpenhamns universitet,University of Copenhagen
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- Straten, P. T. (author)
- Köpenhamns universitet,University of Copenhagen,Copenhagen University Hospital
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- Hojman, P. (author)
- Copenhagen University Hospital,Köpenhamns universitet,University of Copenhagen
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: Cell Metabolism. - : Elsevier BV. - 1932-7420 .- 1550-4131. ; 23:3, s. 554-562
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Abstract
Subject headings
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- Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms behind this protection remain to be elucidated. In this study, tumor-bearing mice randomized to voluntary wheel running showed over 60% reduction in tumor incidence and growth across five different tumor models. Microarray analysis revealed training-induced up-regulation of pathways associated with immune function. NK cell infiltration was significantly increased in tumors from running mice, whereas depletion of NK cells enhanced tumor growth and blunted the beneficial effects of exercise. Mechanistic analyses showed that NK cells were mobilized by epinephrine, and blockade of beta-adrenergic signaling blunted training-dependent tumor inhibition. Moreover, epinephrine induced a selective mobilization of IL-6-sensitive NK cells, and IL-6-blocking antibodies blunted training-induced tumor suppression, intratumoral NK cell infiltration, and NK cell activation. Together, these results link exercise, epinephrine, and IL-6 to NK cell mobilization and redistribution, and ultimately to control of tumor growth.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Keyword
- missing-self-recognition
- il-6
- cytokines
- muscle
- inflammation
- phenotype
- cancer
- natural-killer-cells
- exercise
- physical-activity
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Pedersen, L.
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Idorn, M.
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Olofsson, G. H.
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Lauenborg, B.
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Nookaew, Intawat ...
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Hansen, R. H.
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show more...
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Johannesen, H. H ...
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Becker, J. C.
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Pedersen, K. S.
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Dethlefsen, C.
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Nielsen, Jens B, ...
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Gehl, J.
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Pedersen, B. K.
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Straten, P. T.
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Hojman, P.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
- Articles in the publication
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Cell Metabolism
- By the university
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Chalmers University of Technology