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Trypanosoma brucei:...
Trypanosoma brucei: meet the system
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- Achcar, F. (författare)
- Wellcome Trust Centre for Molecular Parasitology
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- Kerkhoven, Eduard, 1985 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Barrett, M. P. (författare)
- Wellcome Trust Centre for Molecular Parasitology
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- Engelska.
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Ingår i: Current Opinion in Microbiology. - : Elsevier BV. - 1369-5274 .- 1879-0364. ; 20, s. 162-169
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Abstract
Ämnesord
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- African trypanosomes cause devastating diseases in humans and domestic animals. The parasites evolved early in the eukaryotic lineage and have numerous biochemical peculiarities that distinguish them from other systems. These include unconventional mechanisms for expressing nuclear and mitochondrial genes as well as unusual subcellular localizations for a variety of enzymes. Systems biology has arisen partly to allow contextualization of the massive datasets that describe individual chemical parts of biological systems. Here we describe recent efforts to collect and analyse data pertaining to all aspects of the trypanosome's biochemical physiology that go some way to describing the parasite as an integrated system.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- RESISTANCE
- BLOOD-STREAM-FORM
- COMPARATIVE PROTEOMICS
- MITOCHONDRIAL METABOLISM
- PARASITE
- IMMUNE EVASION
- LIFE-CYCLE STAGES
- GENE-EXPRESSION
- DIFFERENTIATION
- AFRICAN TRYPANOSOMES
- ANTIGENIC VARIATION
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