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A Whole-Grain-Rich ...
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Ross, Alastair,1976Chalmers tekniska högskola,Chalmers University of Technology
(author)
A Whole-Grain-Rich Diet Reduces Urinary Excretion of Markers of Protein Catabolism and Gut Microbiota Metabolism in Healthy Men after One Week
- Article/chapterEnglish2013
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Elsevier BV,2013
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electronicrdacarrier
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LIBRIS-ID:oai:research.chalmers.se:b215d895-3795-4bcf-8ef3-22583ec7229b
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https://doi.org/10.3945/jn.112.172197DOI
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https://research.chalmers.se/publication/179802URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Epidemiological studies consistently find that diets rich in whole-grain (WG) cereals lead to decreased risk of disease compared with refined grain (RG)-based diets. Aside from a greater amount of fiber and micronutrients, possible mechanisms for why WGs may be beneficial for health remain speculative. In an exploratory, randomized, researcher-blinded, crossover trial, we measured metabolic profile differences between healthy participants eating a diet based on WGs compared with a diet based on RGs. Seventeen healthy adult participants (11 female, 6 male) consumed a controlled diet based on either WG-rich or RG-rich foods for 2 wk, followed by the other diet after a 5-wk washout period. Both diets were the same except for the use of WG (150 g/d) or FIG foods. The metabolic profiles of plasma, urine, and fecal water were measured using H-1-nuclear magnetic resonance spectroscopy and gas chromatography-mass spectrometry (plasma only). After 1 wk of intervention, the WG diet led to decreases in urinary excretion of metabolites related to protein catabolism (urea, methylguanadine), lipid (carnitine and acylcarnitines) and gut microbial (4-hydroxyphenylacetate, trimethylacetate, dimethylacetate) metabolism in men compared with the same time point during the FIG intervention. There were no differences between the interventions after 2 wk. Urinary urea, carnitine, and acylcarnitine were lower at wk 1 of the WG intervention relative to the FIG intervention in all participants. Fecal water short-chain fatty acids acetate and butyrate were relatively greater after the WG diet compared to the RG diet. Although based on a small population and for a short time period, these observations suggest that a WG diet may affect protein metabolism.
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Pere-Trepat, E.Nestle S.A.
(author)
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Montoliu, I.Nestle S.A.
(author)
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Martin, F. P. J.Nestle S.A.
(author)
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Collino, S.Nestle S.A.
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Moco, S.Nestle S.A.
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Godin, J. P.Nestle S.A.
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Cleroux, M.Nestle S.A.
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Guy, P. A.Nestle S.A.
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Breton, I.Nestle S.A.
(author)
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Bibiloni, R.Nestle S.A.
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Thorimbert, A.Nestle S.A.
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Tavazzi, I.Nestle S.A.
(author)
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Tornier, L.Nestle S.A.
(author)
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Bebuis, A.Nestle S.A.
(author)
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Bruce, S. J.Nestle S.A.
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Beaumont, M.Nestle S.A.
(author)
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Fay, L. B.Nestle S.A.
(author)
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Kochhar, S.Nestle S.A.
(author)
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Chalmers tekniska högskolaNestle S.A.
(creator_code:org_t)
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In:Journal of Nutrition: Elsevier BV143:6, s. 766-7731541-61000022-3166
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Ross, Alastair, ...
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Pere-Trepat, E.
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Montoliu, I.
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Martin, F. P. J.
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Collino, S.
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Moco, S.
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Godin, J. P.
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Cleroux, M.
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Guy, P. A.
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Breton, I.
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Bibiloni, R.
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Thorimbert, A.
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Tavazzi, I.
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Tornier, L.
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Bebuis, A.
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Bruce, S. J.
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Beaumont, M.
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Fay, L. B.
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Kochhar, S.
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Chalmers University of Technology