Sökning: onr:"swepub:oai:research.chalmers.se:e29013fe-32e8-4780-947b-f3d30ee4471b" >
Systematic review w...
Systematic review with meta-analysis: Effects of probiotic supplementation on symptoms in functional dyspepsia
-
- Agah, Shahram (författare)
- University of Adelaide,Iran University of Medical Sciences
-
- Akbari, Abolfazl (författare)
- Iran University of Medical Sciences
-
- Heshmati, Javad (författare)
- Kermanshah University of Medical Sciences
-
visa fler...
-
- Sepidarkish, Mahdi (författare)
- Babol University of Medical Sciences
-
- Morvaridzadeh, Mojgan (författare)
- Kermanshah University of Medical Sciences
-
- Adibi, Payman (författare)
- Isfahan University of Medical Sciences
-
- Mazidi, Mohsen, 1989 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
-
- Farsi, Farnaz (författare)
- Iran University of Medical Sciences
-
- Ofori-Asenso, Richard (författare)
- Monash University
-
- Talley, Nicholas J. (författare)
- University of Newcastle
-
- Feinle-Bisset, Christine (författare)
- University of Adelaide
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska.
-
Ingår i: Journal of Functional Foods. - : Elsevier BV. - 1756-4646. ; 68
- Relaterad länk:
-
https://research.cha... (primary) (free)
-
visa fler...
-
https://doi.org/10.1...
-
https://research.cha...
-
https://doi.org/10.1...
-
https://research.cha...
-
visa färre...
Abstract
Ämnesord
Stäng
- The pathophysiology of functional dyspepsia (FD) remains poorly understood, but alterations of the small intestinal microbiome have been observed. The place of probiotics in treatment is uncertain. We performed a systematic review and meta-analysis of the currently available randomized, controlled trials (RCTs) to evaluate the potential beneficial effects and risks of probiotics in FD. Pubmed, EMBASE, Scopus, Web of Science and the Cochrane Controlled Trials Register were searched (up to May 2019) for RCTs evaluating the effects of probiotic supplementation compared to placebo in adults with FD. Two reviewers independently assessed eligibility, trial quality and extracted information from identified articles. To compare the effects of probiotics with placebo, risk ratios (RRs) with 95% confidence intervals (CIs) were pooled using random effects models. Six trials, including 422 participants were included but only three RCTs could be included in the meta-analysis. Lactobacillus strains showed potential positive effects in terms of improving upper gastrointestinal (GI) symptoms in patients with FD. Probiotic supplementation tended to improve global dyspepsia score (n = 3 RCTs, risk ratio [RR]: 1.35, 95% CI 0.99 to 1.84; P = 0.061) and bacterial composition in the GI tract. Probiotics were well tolerated without any serious adverse events. While the available data suggest that supplementation with probiotics may improve GI symptoms in patients with FD, the evidence is insufficient to draw clear conclusions regarding efficacy. Thus, high-quality RCTs are needed to establish the beneficial effects of probiotic supplementation on FD outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Functional dyspepsia
- Probiotics
- Gastrointestinal
Publikations- och innehållstyp
- for (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Agah, Shahram
-
Akbari, Abolfazl
-
Heshmati, Javad
-
Sepidarkish, Mah ...
-
Morvaridzadeh, M ...
-
Adibi, Payman
-
visa fler...
-
Mazidi, Mohsen, ...
-
Farsi, Farnaz
-
Ofori-Asenso, Ri ...
-
Talley, Nicholas ...
-
Feinle-Bisset, C ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Gastroenterologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Urologi och njur ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Kardiologi
- Artiklar i publikationen
-
Journal of Funct ...
- Av lärosätet
-
Chalmers tekniska högskola