Sökning: onr:"swepub:oai:research.chalmers.se:f873e566-cf05-4094-bbb2-c449da3aeb08" > The Impact of Acute...
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000 | 05688naa a2200637 4500 | |
001 | oai:research.chalmers.se:f873e566-cf05-4094-bbb2-c449da3aeb08 | |
003 | SwePub | |
008 | 230331s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://research.chalmers.se/publication/5352282 URI |
024 | 7 | a https://doi.org/10.1210/clinem/dgad0312 DOI |
040 | a (SwePub)cth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Vernardis,u The Francis Crick Institute4 aut |
245 | 1 0 | a The Impact of Acute Nutritional Interventions on the Plasma Proteome |
264 | c 2023-01-20 | |
264 | 1 | b The Endocrine Society,c 2023 |
338 | a electronic2 rdacarrier | |
520 | a Context: Humans respond profoundly to changes in diet, while nutrition and environment have a great impact on population health. It is therefore important to deeply characterize the human nutritional responses. Objective: Endocrine parameters and the metabolome of human plasma are rapidly responding to acute nutritional interventions such as caloric restriction or a glucose challenge. It is less well understood whether the plasma proteome would be equally dynamic, and whether it could be a source of corresponding biomarkers. Methods: We used high-throughput mass spectrometry to determine changes in the plasma proteome of i) 10 healthy, young, male individuals in response to 2 days of acute caloric restriction followed by refeeding; ii) 200 individuals of the Ely epidemiological study before and after a glucose tolerance test at 4 time points (0, 30, 60, 120 minutes); and iii) 200 random individuals from the Generation Scotland study. We compared the proteomic changes detected with metabolome data and endocrine parameters. Results: Both caloric restriction and the glucose challenge substantially impacted the plasma proteome. Proteins responded across individuals or in an individual-specific manner. We identified nutrient-responsive plasma proteins that correlate with changes in the metabolome, as well as with endocrine parameters. In particular, our study highlights the role of apolipoprotein C1 (APOC1), a small, understudied apolipoprotein that was affected by caloric restriction and dominated the response to glucose consumption and differed in abundance between individuals with and without type 2 diabetes. Conclusion: Our study identifies APOC1 as a dominant nutritional responder in humans and highlights the interdependency of acute nutritional response proteins and the endocrine system. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Annan klinisk medicin0 (SwePub)302992 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Other Clinical Medicine0 (SwePub)302992 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
653 | a oral glucose tolerance test | |
653 | a type 2 diabetes | |
653 | a caloric restriction | |
653 | a plasma proteomics | |
653 | a APOC1 | |
700 | 1 | a Demichev, Vadimu Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut |
700 | 1 | a Lemke, Oliveru Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut |
700 | 1 | a Gruening, Nana-Mariau Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut |
700 | 1 | a Messner, Christophu The Francis Crick Institute4 aut |
700 | 1 | a White, Mattu The Francis Crick Institute4 aut |
700 | 1 | a Pietzner, Maiku Charité Universitätsmedizin Berlin,Charité University Medicine Berlin,University Of Cambridge4 aut |
700 | 1 | a Peluso, Alinau The Francis Crick Institute4 aut |
700 | 1 | a Collet, Tinh-Haiu Université de Genève,University of Geneva,University Of Cambridge4 aut |
700 | 1 | a Henning, Elanau University Of Cambridge4 aut |
700 | 1 | a Gille, Christophu Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut |
700 | 1 | a Campbell, Archieu University of Edinburgh4 aut |
700 | 1 | a Hayward, Carolineu University of Edinburgh4 aut |
700 | 1 | a Porteous, David J.u University of Edinburgh4 aut |
700 | 1 | a Marioni, Riccardo E.u University of Edinburgh4 aut |
700 | 1 | a Muelleder, Michaelu Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut |
700 | 1 | a Zelezniak, Aleksej,d 1984u Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)alezel |
700 | 1 | a Langenberg, Claudiau University Of Cambridge,Queen Mary University of London,Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut |
700 | 1 | a Farooqi, I. Sadafu University Of Cambridge4 aut |
700 | 1 | a Ralser, Markusu The Francis Crick Institute,Charité Universitätsmedizin Berlin,Charité University Medicine Berlin4 aut |
710 | 2 | a The Francis Crick Instituteb Charité Universitätsmedizin Berlin4 org |
773 | 0 | t Journal of Clinical Endocrinology and Metabolismd : The Endocrine Societyg 108:8, s. 2087-2098q 108:8<2087-2098x 1945-7197x 0021-972X |
856 | 4 | u https://research.chalmers.se/publication/535228/file/535228_Fulltext.pdfx primaryx freey FULLTEXT |
856 | 4 8 | u https://research.chalmers.se/publication/535228 |
856 | 4 8 | u https://doi.org/10.1210/clinem/dgad031 |
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