Fragment-based approaches in drug discovery / edited by Wolfgang Jahnke and Daniel A. Erlanson.

• The concept of fragment-based drug discovery / Daniel A. Erlanson and Wolfgang Jahnke -- Multivalency in ligand design / Vijay M. Krishnamurthy, Lara A. Estroff, and George M. Whitesides -- Entropic consequences of linking ligands / Christopher W. Murray and Marcel L. Verdonk -- Location of binding sites on proteins by the multiple solvent crystal structure method / Dagmar Ringe and Carla Mattos -- Cheminformatics approaches to fragment-based lead discovery / Tudor I. Oprea and Jeffrey M. Blaney -- Structural fragments in marketed oral drugs / Michal Vieth and Miles Siegel -- Fragment docking to proteins with the multi-copy simultaneous search methodology / Collin M. Stultz and Martin Karplus -- NMR-guided fragment assembly / Daniel S. Sem -- SAR by NMR : an analysis of potency gains realized through fragment-linking and fragment-elaboration strategies for lead generation / Philip J. Hajduk, Jeffrey R. Huth, and Chaohong Sun -- Pyramid : an integrated platform for fragment-based drug discovery / Thomas G. Davies, Rob L.M. van Montfort, Glyn Williams, and Harren Jhoti -- Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high-throughput organic synthesis / Jeff Blaney, Vicki Nienaber, and Stephen K. Burley -- Synergistic use of protein crystallography and solution-phase NMR spectroscopy in structure-based drug design : strategies and tactics / Cele Abad-Zapatero, Geoffrey F. Stamper, and Vincent S. Stoll -- Ligand SAR using electrospray ionizing mass spectrometry / Richard H. Griffey and Eric E. Swayze -- Tethering / Daniel A. Erlanson, Marcus D. Ballinger, and James A. Wells -- Click chemistry for drug discovery / Stefanie Röper and Hartmuth C. Kolb -- Dynamic combinatorial diversity in drug discovery / Matthias Hochgürtel and Jean-Marie Lehn.

• This first systematic summary of the impact of fragment-based approaches on the drug development process provides essential information that was previously unavailable. Adopting a practice-oriented approach, this represents a book by professionals for professionals, tailor-made for drug developers in the pharma and biotech sector who need to keep up-to-date on the latest technologies and strategies in pharmaceutical ligand design. The book is clearly divided into three sections on ligand design, spectroscopic techniques, and screening and drug discovery, backed by numerous case studies.

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Ämnesord

Drug development.  (LCSH)

Ligands (Biochemistry)  (LCSH)

Drug Design.  (MeSH)

Ligands.  (MeSH)

MEDICAL  -- Drug Guides. (bisacsh)

MEDICAL  -- Pharmacology. (bisacsh)

MEDICAL  -- Pharmacy. (bisacsh)

MEDICAL  -- Nursing -- Pharmacology. (bisacsh)

Genre

Electronic books. 

Publikations- och innehållstyp

RM301.25 (LCC)

W1 (NLM)

QV 744 (NLM)

MED (ämneskategori)

MED (ämneskategori)

MED (ämneskategori)

MED (ämneskategori)

615.1901 (DDC)

Pmca (kssb/8 (machine generated))