Search: WFRF:(Schmid E) >
Climbing
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
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de Rojas, I. (author)
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Moreno-Grau, S. (author)
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- Tesi, N. (author)
- Karolinska Institutet
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Grenier-Boley, B. (author)
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Andrade, V. (author)
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Jansen, I. E. (author)
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- Pedersen, N. L. (author)
- Karolinska Institutet
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Stringa, N. (author)
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- Zettergren, Anna, 1978 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
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Hernández, I. (author)
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Montrreal, L. (author)
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Antúnez, C. (author)
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- Antonell, A. (author)
- Karolinska Institutet
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Tankard, R. M. (author)
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Bis, J. C. (author)
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Sims, R. (author)
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Bellenguez, C. (author)
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Quintela, I. (author)
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González-Perez, A. (author)
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Calero, M. (author)
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Franco-Macías, E. (author)
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Macías, J. (author)
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Blesa, R. (author)
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Cervera-Carles, L. (author)
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Menéndez-González, M. (author)
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Frank-García, A. (author)
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Royo, J. L. (author)
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Moreno, F. (author)
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Huerto Vilas, R. (author)
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Baquero, M. (author)
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- Diez-Fairen, M. (author)
- Karolinska Institutet
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Lage, C. (author)
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García-Madrona, S. (author)
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- García-González, P. (author)
- Karolinska Institutet
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Alarcón-Martín, E. (author)
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Valero, S. (author)
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Sotolongo-Grau, O. (author)
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Ullgren, A. (author)
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Naj, A. C. (author)
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Lemstra, A. W. (author)
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Benaque, A. (author)
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Pérez-Cordón, A. (author)
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Benussi, A. (author)
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Rábano, A. (author)
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Padovani, A. (author)
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Squassina, A. (author)
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- de Mendonça, A. (author)
- Karolinska Institutet
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Arias Pastor, A. (author)
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Kok, A. A. L. (author)
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Meggy, A. (author)
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Pastor, A. B. (author)
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Espinosa, A. (author)
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Corma-Gómez, A. (author)
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Martín Montes, A. (author)
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Sanabria, Á (author)
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DeStefano, A. L. (author)
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Schneider, A. (author)
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Haapasalo, A. (author)
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Kinhult Ståhlbom, A. (author)
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Tybjærg-Hansen, A. (author)
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Hartmann, A. M. (author)
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Spottke, A. (author)
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Corbatón-Anchuelo, A. (author)
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Rongve, A. (author)
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Borroni, B. (author)
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Arosio, B. (author)
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Nacmias, B. (author)
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- Nordestgaard, B. G. (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Kunkle, B. W. (author)
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- Charbonnier, C. (author)
- Karolinska Institutet
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Abdelnour, C. (author)
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Masullo, C. (author)
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Martínez Rodríguez, C. (author)
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Muñoz-Fernandez, C. (author)
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Dufouil, C. (author)
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Graff, C. (author)
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Ferreira, C. B. (author)
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Chillotti, C. (author)
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Reynolds, C. A. (author)
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Fenoglio, C. (author)
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Van Broeckhoven, C. (author)
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Clark, C. (author)
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Pisanu, C. (author)
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Satizabal, C. L. (author)
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Holmes, C. (author)
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Buiza-Rueda, D. (author)
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Aarsland, D. (author)
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Rujescu, D. (author)
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Alcolea, D. (author)
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Galimberti, D. (author)
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Wallon, D. (author)
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Seripa, D. (author)
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Grünblatt, E. (author)
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Dardiotis, E. (author)
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Düzel, E. (author)
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Scarpini, E. (author)
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Conti, E. (author)
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Rubino, E. (author)
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Gelpi, E. (author)
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Rodriguez-Rodriguez, E. (author)
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Duron, E. (author)
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Boerwinkle, E. (author)
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Ferri, E. (author)
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Tagliavini, F. (author)
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Küçükali, F. (author)
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Pasquier, F. (author)
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Sanchez-Garcia, F. (author)
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Mangialasche, F. (author)
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Jessen, F. (author)
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Nicolas, G. (author)
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Selbæk, G. (author)
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Ortega, G. (author)
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Chêne, G. (author)
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Hadjigeorgiou, G. (author)
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Rossi, G. (author)
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Spalletta, G. (author)
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Giaccone, G. (author)
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Grande, G. (author)
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Binetti, G. (author)
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- Papenberg, G. (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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Hampel, H. (author)
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Bailly, H. (author)
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Soininen, H. (author)
- Karolinska Institutet
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- Karlsson, Ida K. (author)
- Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Alvarez, I. (author)
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Appollonio, I. (author)
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Giegling, I. (author)
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- Skoog, Ingmar, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
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Saltvedt, I. (author)
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Rainero, I. (author)
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Rosas Allende, I. (author)
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Hort, J. (author)
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Diehl-Schmid, J. (author)
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Van Dongen, J. (author)
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Vidal, J. S. (author)
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Lehtisalo, J. (author)
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Wiltfang, J. (author)
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Thomassen, J. Q. (author)
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Kornhuber, J. (author)
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Haines, J. L. (author)
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Vogelgsang, J. (author)
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Pineda, J. A. (author)
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Fortea, J. (author)
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Popp, J. (author)
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Deckert, J. (author)
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Buerger, K. (author)
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- Morgan, K. (author)
- Karolinska Institutet
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Fließbach, K. (author)
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Sleegers, K. (author)
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Molina-Porcel, L. (author)
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- Kilander, Lena (author)
- Uppsala universitet,Geriatrik
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Weinhold, L. (author)
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Farrer, L. A. (author)
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Wang, L. S. (author)
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Kleineidam, L. (author)
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Farotti, L. (author)
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Parnetti, L. (author)
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Tremolizzo, L. (author)
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Hausner, L. (author)
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Benussi, L. (author)
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Froelich, L. (author)
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Ikram, M. A. (author)
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Deniz-Naranjo, M. C. (author)
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Tsolaki, M. (author)
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Rosende-Roca, M. (author)
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Löwenmark, M. (author)
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Hulsman, M. (author)
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Spallazzi, M. (author)
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Pericak-Vance, M. A. (author)
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Esiri, M. (author)
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Bernal Sánchez-Arjona, M. (author)
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Dalmasso, M. C. (author)
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Martínez-Larrad, M. T. (author)
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Arcaro, M. (author)
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Nöthen, M. M. (author)
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Fernández-Fuertes, M. (author)
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Dichgans, M. (author)
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- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik
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Herrmann, M. J. (author)
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Scherer, M. (author)
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Vyhnalek, M. (author)
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Kosmidis, M. H. (author)
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Yannakoulia, M. (author)
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Schmid, M. (author)
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Ewers, M. (author)
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Heneka, M. T. (author)
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Wagner, M. (author)
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Scamosci, M. (author)
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Kivipelto, M. (author)
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Hiltunen, M. (author)
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Zulaica, M. (author)
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Alegret, M. (author)
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Fornage, M. (author)
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Roberto, N. (author)
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van Schoor, N. M. (author)
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- Seidu, Nazib (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
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Banaj, N. (author)
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Armstrong, N. J. (author)
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Scarmeas, N. (author)
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Scherbaum, N. (author)
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Goldhardt, O. (author)
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Hanon, O. (author)
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Peters, O. (author)
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Skrobot, O. A. (author)
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Quenez, O. (author)
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Lerch, O. (author)
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Bossù, P. (author)
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Caffarra, P. (author)
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Dionigi Rossi, P. (author)
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Sakka, P. (author)
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Hoffmann, P. (author)
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Holmans, P. A. (author)
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Fischer, P. (author)
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Riederer, P. (author)
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Yang, Q. (author)
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Marshall, R. (author)
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Kalaria, R. N. (author)
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Mayeux, R. (author)
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Vandenberghe, R. (author)
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Cecchetti, R. (author)
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Ghidoni, R. (author)
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Frikke-Schmidt, R. (author)
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Sorbi, S. (author)
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Hägg, S. (author)
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Engelborghs, S. (author)
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Helisalmi, S. (author)
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Botne Sando, S. (author)
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- Kern, Silke (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Centrum för åldrande och hälsa (AgeCap),Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Centre for Ageing and Health (Agecap)
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Archetti, S. (author)
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Boschi, S. (author)
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Fostinelli, S. (author)
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Gil, S. (author)
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Mendoza, S. (author)
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Mead, S. (author)
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Ciccone, S. (author)
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Djurovic, S. (author)
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Heilmann-Heimbach, S. (author)
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Riedel-Heller, S. (author)
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Kuulasmaa, T. (author)
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del Ser, T. (author)
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Lebouvier, T. (author)
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Polak, T. (author)
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Ngandu, T. (author)
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Grimmer, T. (author)
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Bessi, V. (author)
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Escott-Price, V. (author)
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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Deramecourt, V. (author)
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Maier, W. (author)
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Jian, X. (author)
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Pijnenburg, Y. A. L. (author)
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Smith, A. D. (author)
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Saenz, A. (author)
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Bizzarro, A. (author)
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Lauria, A. (author)
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Vacca, A. (author)
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Solomon, A. (author)
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Anastasiou, A. (author)
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Richardson, A. (author)
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Boland, A. (author)
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Koivisto, A. (author)
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Daniele, A. (author)
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Greco, A. (author)
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Marianthi, A. (author)
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McGuinness, B. (author)
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Fin, B. (author)
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Ferrari, C. (author)
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Custodero, C. (author)
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Ferrarese, C. (author)
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Ingino, C. (author)
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Mangone, C. (author)
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Reyes Toso, C. (author)
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Martínez, C. (author)
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Cuesta, C. (author)
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Muchnik, C. (author)
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Joachim, C. (author)
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Ortiz, C. (author)
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Besse, C. (author)
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Johansson, C. (author)
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Zoia, C. P. (author)
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Laske, C. (author)
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Anastasiou, C. (author)
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Palacio, D. L. (author)
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Politis, D. G. (author)
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Janowitz, D. (author)
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Craig, D. (author)
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Mann, D. M. (author)
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Neary, D. (author)
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Jürgen, D. (author)
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Daian, D. (author)
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Belezhanska, D. (author)
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Kohler, E. (author)
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Castaño, E. M. (author)
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Koutsouraki, E. (author)
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Chipi, E. (author)
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De Roeck, E. (author)
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Costantini, E. (author)
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Vardy, E. R. L. C. (author)
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Piras, F. (author)
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Roveta, F. (author)
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Piras, F. (author)
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Prestia, F. A. (author)
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Assogna, F. (author)
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Salani, F. (author)
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Sala, G. (author)
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Lacidogna, G. (author)
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Novack, G. (author)
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Wilcock, G. (author)
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Thonberg, H. (author)
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Kölsch, H. (author)
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Weber, H. (author)
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Boecker, H. (author)
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Etchepareborda, I. (author)
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Piaceri, I. (author)
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Tuomilehto, J. (author)
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Lindström, J. (author)
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Laczo, J. (author)
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Johnston, J. (author)
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Deleuze, J. F. (author)
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Harris, J. (author)
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Schott, J. M. (author)
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Priller, J. (author)
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Bacha, J. I. (author)
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Snowden, J. (author)
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Lisso, J. (author)
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Mihova, K. Y. (author)
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Traykov, L. (author)
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Morelli, L. (author)
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Brusco, L. I. (author)
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Rainer, M. (author)
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Takalo, M. (author)
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Bjerke, M. (author)
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Del Zompo, M. (author)
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Serpente, M. (author)
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Sanchez Abalos, M. (author)
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Rios, M. (author)
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Peltonen, M. (author)
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Herrman, M. J. (author)
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Kosmidis, M. H. (author)
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Kohler, M. (author)
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Rojo, M. (author)
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Jones, M. (author)
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Orsini, M. (author)
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Medel, N. (author)
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Olivar, N. (author)
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Fox, N. C. (author)
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Salvadori, N. (author)
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Hooper, N. M. (author)
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Galeano, P. (author)
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Solis, P. (author)
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Bastiani, P. (author)
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Mecocci, P. (author)
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Passmore, P. (author)
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Heun, R. (author)
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Antikainen, R. (author)
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Olaso, R. (author)
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Perneczky, R. (author)
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Germani, S. (author)
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López-García, S. (author)
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Love, S. (author)
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Mehrabian, S. (author)
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Bagnoli, S. (author)
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Kochen, S. (author)
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Andreoni, S. (author)
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Teipel, S. (author)
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Todd, S. (author)
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Pickering-Brown, S. (author)
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Natunen, T. (author)
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Tegos, T. (author)
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Laatikainen, T. (author)
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Strandberg, T. (author)
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Polvikoski, T. M. (author)
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Matoska, V. (author)
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Ciullo, V. (author)
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Cores, V. (author)
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Solfrizzi, V. (author)
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Lisetti, V. (author)
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Sevillano, Z. (author)
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Abdelnour, C. (author)
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Aguilera, N. (author)
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Alarcon, E. (author)
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Alegret, M. (author)
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Benaque, A. (author)
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Boada, M. (author)
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Buendia, M. (author)
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Cañabate, P. (author)
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Carracedo, A. (author)
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Corbatón-Anchuelo, A. (author)
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de Rojas, I. (author)
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Diego, S. (author)
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Espinosa, A. (author)
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Gailhajenet, A. (author)
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García-González, P. (author)
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Gil, S. (author)
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Guitart, M. (author)
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González-Pérez, A. (author)
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Hernández, I. (author)
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Ibarria, M. (author)
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Lafuente, A. (author)
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Macias, J. (author)
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Maroñas, O. (author)
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Martín, E. (author)
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Martínez, M. T. (author)
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Marquié, M. (author)
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Mauleón, A. (author)
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Montrreal, L. (author)
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Moreno-Grau, S. (author)
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Moreno, M. (author)
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Orellana, A. (author)
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Ortega, G. (author)
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Pancho, A. (author)
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Pelejá, E. (author)
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Pérez-Cordon, A. (author)
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Pineda, J. A. (author)
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Preckler, S. (author)
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Quintela, I. (author)
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Real, L. M. (author)
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Rosende-Roca, M. (author)
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Ruiz, A. (author)
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Sáez, M. E. (author)
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Sanabria, A. (author)
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Serrano-Rios, M. (author)
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Sotolongo-Grau, O. (author)
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Tárraga, L. (author)
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Valero, S. (author)
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Vargas, L. (author)
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Adarmes-Gómez, A. D. (author)
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Alarcón-Martín, E. (author)
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Alonso, M. D. (author)
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Álvarez, I. (author)
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Álvarez, V. (author)
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Amer-Ferrer, G. (author)
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Antequera, M. (author)
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Antúnez, C. (author)
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Baquero, M. (author)
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Bernal, M. (author)
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Blesa, R. (author)
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Boada, M. (author)
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Buiza-Rueda, D. (author)
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Bullido, M. J. (author)
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Burguera, J. A. (author)
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Calero, M. (author)
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Carrillo, F. (author)
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Carrión-Claro, M. (author)
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Casajeros, M. J. (author)
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Clarimón, J. (author)
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Cruz-Gamero, J. M. (author)
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de Pancorbo, M. M. (author)
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de Rojas, I. (author)
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del Ser, T. (author)
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Diez-Fairen, M. (author)
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Escuela, R. (author)
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Garrote-Espina, L. (author)
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Fortea, J. (author)
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Franco-Macías, E. (author)
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Frank-García, A. (author)
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García-Alberca, J. M. (author)
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Garcia Madrona, S. (author)
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Garcia-Ribas, G. (author)
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Gómez-Garre, P. (author)
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Hernández, I. (author)
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Hevilla, S. (author)
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Jesús, S. (author)
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Labrador Espinosa, M. A. (author)
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Lage, C. (author)
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Legaz, A. (author)
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Lleó, A. (author)
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Lopez de Munain, A. (author)
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López-García, S. (author)
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Macias-García, D. (author)
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Manzanares, S. (author)
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Marín, M. (author)
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Marín-Muñoz, J. (author)
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Marín, T. (author)
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Marquié, M. (author)
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Martín Montes, A. (author)
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Martínez, B. (author)
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Martínez, C. (author)
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Martínez, V. (author)
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Martínez-Lage Álvarez, P. (author)
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Medina, M. (author)
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Mendioroz Iriarte, M. (author)
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Menéndez-González, M. (author)
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Mir, P. (author)
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Molinuevo, J. L. (author)
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Pastor, P. (author)
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Pérez Tur, J. (author)
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Periñán-Tocino, T. (author)
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Pineda-Sanchez, R. (author)
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Piñol-Ripoll, G. (author)
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Rábano, A. (author)
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Real de Asúa, D. (author)
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Rodrigo, S. (author)
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Rodríguez-Rodríguez, E. (author)
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Royo, J. L. (author)
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Ruiz, A. (author)
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Sanchez del Valle Díaz, R. (author)
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Sánchez-Juan, P. (author)
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Sastre, I. (author)
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Valero, S. (author)
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Vicente, M. P. (author)
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Vigo-Ortega, R. (author)
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Vivancos, L. (author)
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Huisman, M. (author)
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Andreassen, O. A. (author)
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(creator_code:org_t)
- 2021-06-07
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
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Table of contents
Abstract
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- Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease. © 2021, The Author(s).
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Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- detection method
- genetic analysis
- nervous system disorder
- public health
- risk assessment
- risk factor
- stratification
- amyloid precursor protein
- apolipoprotein E
- APP protein
- human
- aged
- Alzheimer disease
- case control study
- cohort analysis
- female
- follow up
- genetic predisposition
- genetics
- genome-wide association study
- heterozygote
- human
- information processing
- male
- metabolism
- middle aged
- multifactorial inheritance
- onset age
- pathology
- procedures
- single nucleotide polymorphism
- very elderly
- Age of Onset
- Aged
- 80 and over
- Amyloid beta-Protein Precursor
- Apolipoproteins E
- Case-Control Studies
- Cohort Studies
- Datasets as Topic
- Follow-Up Studies
- Genetic Predisposition to Disease
- Humans
- Polymorphism
- Single Nucleotide
- Risk Factors
- detection method
Publication and Content Type
- ref (subject category)
- art (subject category)
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