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Common variants in ...
Common variants in the ARC gene are not associated withcognitive abilities
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Myrum, Craig (författare)
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Giddaluru, Sudheer (författare)
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Jacobsen, Kaya (författare)
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Espeseth, Thomas (författare)
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Nyberg, Lars (författare)
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Lundervold, Astri J. (författare)
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Haavik, Jan (författare)
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Nilsson, Lars Göran, 1944- (författare)
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Reinvang, Ivar (författare)
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Steen, Vidar M. (författare)
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Johansson, Stefan (författare)
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Wibrand, Karin (författare)
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Le Hellard, Stephanie (författare)
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Bramham, Clive R. (författare)
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(utgivare)
- John Wiley & Sons, 2015
- 2015
- Engelska.
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Ingår i: Brain and Behavior. - 2162-3279. ; 5 10
- Relaterad länk:
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http://www.umu.se/ (web site)
Abstract
Ämnesord
Stäng
- Introduction: The Activity-Regulated Cytoskeleton-associated (ARC) gene encodes a protein that is critical for the consolidation of synaptic plasticity and long-term memory formation. Given ARC's key role in synaptic plasticity, we hypothesized that genetic variations in ARC may contribute to interindividual variability in human cognitive abilities or to attention-deficit hyperactivity disorder (ADHD) susceptibility, where cognitive impairment often accompanies the disorder. Methods: We tested whether ARC variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS). In addition, the Swedish Betula sample of 1800 healthy subjects who underwent similar cognitive testing was also tested for association with 19 tag SNPs. Results: No ARC variants show association at the study-wide level, but several markers show a trend toward association with human cognitive functions. We also tested for association between ARCSNPs and ADHD in a Norwegian sample of cases and controls, but found no significant associations. Conclusion: This study suggests that common genetic variants located in ARC do not account for variance in human cognitive abilities, though small effects cannot be ruled out.
Genre
- government publication (marcgt)
Nyckelord
- Activity-regulated cytoskeleton-associated protein
- cognition
- genetics
- memory
- single-nucleotide polymorphism
- synaptic plasticity
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Myrum, Craig
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Giddaluru, Sudhe ...
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Jacobsen, Kaya
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Espeseth, Thomas
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Nyberg, Lars
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Lundervold, Astr ...
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visa fler...
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Haavik, Jan
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Nilsson, Lars Gö ...
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Reinvang, Ivar
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Steen, Vidar M.
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Johansson, Stefa ...
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Wibrand, Karin
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Le Hellard, Step ...
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Bramham, Clive R ...
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visa färre...
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