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Ischemic heart dise...
Ischemic heart disease among subjects with and without chronic obstructive pulmonary disease ECG-findings in a population-based cohort study
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Nilsson, Ulf 1974- (författare)
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Johansson, Bengt (författare)
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Eriksson, Berne (författare)
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visa fler...
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Blomberg, Anders (författare)
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Lundbäck, Bo (författare)
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Lindberg, Anne (författare)
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visa färre...
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(utgivare)
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(utgivare)
- Umeå 2015
- 2015
- Engelska.
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Ingår i: BMC Pulmonary Medicine. - 1471-2466. ; 15
Abstract
Ämnesord
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- Background: Cardiovascular comorbidity in COPD is common and contributes to increased mortality. A few population-based studies indicate that ischemic electrocardiogram (ECG)-changes are more prevalent in COPD, while others do not. The aim of the present study was to estimate the presence of ischemic heart disease (IHD) in a population-based COPD-cohort in comparison with subjects without COPD. Methods: All subjects with obstructive lung function (COPD, n = 993) were identified together with age- and sex-matched controls (non-COPD, n = 993) from population-based cohorts examined in 2002–04. In 2005, data from structured interview, spirometry and ECG were collected from 1625 subjects. COPD was classified into GOLD 1–4 after post-bronchodilator spirometry. Ischemic ECG-changes, based on Minnesota-coding, were classified according to the Whitehall criteria into probable and possible IHD. Results: Self-reported IHD was equally common in COPD and non-COPD, and so were probable and possible ischemic ECG-changes according to Whitehall. After excluding subjects with restrictive spirometric pattern from the non-COPD-group, similar comparison with regard to presence of IHD performed between those with COPD and those with normal lung-function did neither show any differences. There was a significant association between self-reported IHD (p = 0.007) as well as probable ischemic ECG-changes (p = 0.042), and increasing GOLD stage. In COPD there was a significant association between level of FEV1 percent of predicted and self-reported as well as probable ischemic ECG-changes, and this association persisted for self-reported IHD also after adjustment for sex and age. Conclusion: In this population-based study, self-reported IHD and probable ischemic ECG-changes were associated with COPD disease severity assessed by spirometry.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cardiac and Cardiovascular Systems (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Kardiologi (hsv)
- kardiologi (umu)
- Cardiology (umu)
Nyckelord
- Comorbidity
- Epidemiology
- Coronary disease
- Respiratory diseases
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