Search: WFRF:(Baldassarre Damiano)
> (2015) >
Sex-Specific Effect...
Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease
- E-article/E-chapterEnglish2015
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:19660737
-
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-112288uri
-
urn:nbn:se:umu:diva-112288urn
-
10.1161/JAHA.115.001853doi
Supplementary language notes
Part of subdatabase
Notes
-
Published
-
gratis
-
Background-Plasma adiponectin levels have previously been inversely associated with carotid intima-media thickness (IMT), a marker of subclinical atherosclerosis. In this study, we used a sex-stratified Mendelian randomization approach to investigate whether adiponectin has a causal protective influence on IMT. Methods and Results-Baseline plasma adiponectin concentrationwas tested for association with baseline IMT, IMT progression over 30 months, and occurrence of cardiovascular events within 3 years in 3430 participants (women, n=1777; men, n=1653) with high cardiovascular risk but no prevalent disease. Plasma adiponectin levels were inversely associated with baseline mean bifurcation IMT after adjustment for established risk factors (beta=-0.018, P<0.001) in men but not in women (beta=-0.006, P=0.185; P for interaction=0.061). Adiponectin levels were inversely associated with progression of mean common carotid IMT in men (beta=-0.0022, P=0.047), whereas no association was seen in women (0.0007, P=0.475; P for interaction=0.018). Moreover, we observed that adiponectin levels were inversely associated with coronary events in women (hazard ratio 0.57, 95% CI 0.37 to 0.87) but not in men (hazard ratio 0.82,95% CI0.54 to 1.25). Agenescore of adiponectin-raisingalleles in6loci, reported recently inalarge multi-ethnic metaanalysis, was inversely associated with baseline mean bifurcation IMT in men (beta=-0.0008, P=0.004) but not in women (beta=-0.0003, P=0.522; P for interaction=0.007). Conclusions-This report provides some evidence for adiponectin protecting against atherosclerosis, with effects being confined to men; however, compared with established cardiovascular risk factors, the effect of plasma adiponectin was modest. Further investigation involving mechanistic studies is warranted.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Strawbridge, Rona J.
(author)
-
McLeod, Olga
(author)
-
Gertow, Karl
(author)
-
Silveira, Angela
(author)
-
Baldassarre, Damiano
(author)
-
Van Zuydam, Natalie
(author)
-
Shah, Sonia
(author)
-
Fava, Cristiano
(author)
-
Gustafsson, Stefan
(author)
-
Veglia, Fabrizio
(author)
-
Sennblad, Bengt
(author)
-
Larsson, Malin
(author)
-
Sabater-Lleal, Maria
(author)
-
Leander, Karin
(author)
-
Gigante, Bruna
(author)
-
Tabak, Adam
(author)
-
Kivimaki, Mika
(author)
-
Kauhanen, Jussi
(author)
-
Rauramaa, Rainer
(author)
-
Smit, Andries J.
(author)
-
Mannarino, Elmo
(author)
-
Giral, Philippe
(author)
-
Humphries, Steve E.
(author)
-
Tremoli, Elena
(author)
-
de Faire, Ulf
(author)
-
Lind, Lars
(author)
-
Ingelsson, Erik
(author)
-
Hedblad, Bo
(author)
-
Melander, Olle
(author)
-
Kumari, Meena
(author)
-
Hingorani, Aroon
(author)
-
Morris, Andrew D.
(author)
-
Palmer, Colin N. A.
(author)
-
Lundman, Pia
(author)
-
Ohrvik, John
(author)
-
Söderberg, Stefan
(author)
-
Umeå universitetMedicinska fakulteten268483
(publisher)
Related titles
-
Part of/supplement to:channel record
-
In:VärdpublikationJournal of the American Heart Association4 82047-9980
Internet link
Find in a library
To the university's database
- By the author/editor
-
Persson, Jonas
-
Strawbridge, Ron ...
-
McLeod, Olga
-
Gertow, Karl
-
Silveira, Angela
-
Baldassarre, Dam ...
-
show more...
-
Van Zuydam, Nata ...
-
Shah, Sonia
-
Fava, Cristiano
-
Gustafsson, Stef ...
-
Veglia, Fabrizio
-
Sennblad, Bengt
-
Larsson, Malin
-
Sabater-Lleal, M ...
-
Leander, Karin
-
Gigante, Bruna
-
Tabak, Adam
-
Kivimaki, Mika
-
Kauhanen, Jussi
-
Rauramaa, Rainer
-
Smit, Andries J.
-
Mannarino, Elmo
-
Giral, Philippe
-
Humphries, Steve ...
-
Tremoli, Elena
-
de Faire, Ulf
-
Lind, Lars
-
Ingelsson, Erik
-
Hedblad, Bo
-
Melander, Olle
-
Kumari, Meena
-
Hingorani, Aroon
-
Morris, Andrew D ...
-
Palmer, Colin N. ...
-
Lundman, Pia
-
Ohrvik, John
-
Söderberg, Stefa ...
-
show less...
- By the university
-
Swepub_uni:_t