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Physical activity, ...
Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan the PROMIS study
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Ahmad, Shafqat (författare)
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Zhao, Wei (författare)
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Renström, Frida (författare)
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visa fler...
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Rasheed, Asif (författare)
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Samuel, Maria (författare)
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Zaidi, Mozzam (författare)
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Shah, Nabi (författare)
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Mallick, Nadeem Hayyat (författare)
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Zaman, Khan Shah (författare)
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Ishaq, Mohammad (författare)
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Rasheed, Syed Zahed (författare)
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Memon, Fazal-ur-Rheman (författare)
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Hanif, Bashir (författare)
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Lakhani, Muhammad Shakir (författare)
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Ahmed, Faisal (författare)
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Kazmi, Shahana Urooj (författare)
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Frossard, Philippe (författare)
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Franks, Paul W. (författare)
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Saleheen, Danish (författare)
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(utgivare)
- BioMed Central 2015
- 2015
- Engelska.
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Ingår i: BMC Medical Genetics. - 1471-2350. ; 16
Abstract
Ämnesord
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- Background: Multiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians. Methods: In 16,157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated loci, individually or in aggregate (as a genetic risk score - GRS), are associated with BMI; b) physical activity and smoking modify the association of these loci with BMI. Analyses were adjusted for age, age(2), sex, MI (yes/no), and population substructure. Results: Of 95 SNPs studied here, 73 showed directionally consistent effects on BMI as reported in Europeans. Each additional BMI-raising allele of the GRS was associated with 0.04 (SE = 0.01) kg/m(2) higher BMI (P = 4.5 x 10(-14)). We observed nominal evidence of interactions of CLIP1 rs11583200 (P-interaction = 0.014), CADM2 rs13078960 (P-interaction = 0.037) and GALNT10 rs7715256 (P-interaction = 0.048) with physical activity, and PTBP2 rs11165643 (P-interaction = 0.045), HIP1 rs1167827 (P-interaction = 0.015), C6orf106 rs205262 (P-interaction = 0.032) and GRID1 rs7899106 (P-interaction = 0.043) with smoking on BMI. Conclusions: Most BMI-associated loci have directionally consistent effects on BMI in Pakistanis and Europeans. There were suggestive interactions of established BMI-related SNPs with smoking or physical activity.
Ämnesord
- Medical and Health Sciences (hsv)
- Health Sciences (hsv)
- Public Health, Global Health, Social Medicine and Epidemiology (hsv)
- Medicin och hälsovetenskap (hsv)
- Hälsovetenskaper (hsv)
- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv)
Nyckelord
- Obesity
- Physical activity
- Smoking
- Genetic susceptibility
- Gene-lifestyle interactions
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Till lärosätets databas
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Ahmad, Shafqat
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Zhao, Wei
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Renström, Frida
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Rasheed, Asif
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Samuel, Maria
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Zaidi, Mozzam
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visa fler...
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Shah, Nabi
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Mallick, Nadeem ...
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Zaman, Khan Shah
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Ishaq, Mohammad
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Rasheed, Syed Za ...
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Memon, Fazal-ur- ...
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Hanif, Bashir
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Lakhani, Muhamma ...
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Ahmed, Faisal
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Kazmi, Shahana U ...
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Frossard, Philip ...
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Franks, Paul W.
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Saleheen, Danish
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visa färre...
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