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New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

Lu, Yingchang (author)
Day, Felix R. (author)
Gustafsson, Stefan (author)
show more...
Buchkovich, Martin L. (author)
Na, Jianbo (author)
Bataille, Veronique (author)
Cousminer, Diana L. (author)
Dastani, Zari (author)
Drong, Alexander W. (author)
Esko, Tonu (author)
Evans, David M. (author)
Falchi, Mario (author)
Feitosa, Mary F. (author)
Ferreira, Teresa (author)
Hedman, Asa K. (author)
Haring, Robin (author)
Hysi, Pirro G. (author)
Iles, Mark M. (author)
Justice, Anne E. (author)
Kanoni, Stavroula (author)
Lagou, Vasiliki (author)
Li, Rui (author)
Li, Xin (author)
Locke, Adam (author)
Lu, Chen (author)
Magi, Reedik (author)
Perry, John R. B. (author)
Pers, Tune H. (author)
Qi, Qibin (author)
Sanna, Marianna (author)
Schmidt, Ellen M. (author)
Scott, William R. (author)
Shungin, Dmitry (author)
Teumer, Alexander (author)
Vinkhuyzen, Anna A. E. (author)
Walker, Ryan W. (author)
Westra, Harm-Jan (author)
Zhang, Mingfeng (author)
Zhang, Weihua (author)
Zhao, Jing Hua (author)
Zhu, Zhihong (author)
Afzal, Uzma (author)
Ahluwalia, Tarunveer Singh (author)
Bakker, Stephan J. L. (author)
Bellis, Claire (author)
Bonnefond, Amelie (author)
Borodulin, Katja (author)
Buchman, Aron S. (author)
Cederholm, Tommy (author)
Choh, Audrey C. (author)
Choi, Hyung Jin (author)
Curran, Joanne E. (author)
de Groot, Lisette C. P. G. M. (author)
De Jager, Philip L. (author)
Dhonukshe-Rutten, Rosalie A. M. (author)
Enneman, Anke W. (author)
Eury, Elodie (author)
Evans, Daniel S. (author)
Forsen, Tom (author)
Friedrich, Nele (author)
Fumeron, Frederic (author)
Garcia, Melissa E. (author)
Gartner, Simone (author)
Han, Bok-Ghee (author)
Havulinna, Aki S. (author)
Hayward, Caroline (author)
Hernandez, Dena (author)
Hillege, Hans (author)
Ittermann, Till (author)
Kent, Jack W. (author)
Kolcic, Ivana (author)
Laatikainen, Tiina (author)
Lahti, Jari (author)
Leach, Irene Mateo (author)
Lee, Christine G. (author)
Lee, Jong-Young (author)
Liu, Tian (author)
Liu, Youfang (author)
Lobbens, Stephane (author)
Loh, Marie (author)
Lyytikainen, Leo-Pekka (author)
Medina-Gomez, Carolina (author)
Michaelsson, Karl (author)
Nalls, Mike A. (author)
Nielson, Carrie M. (author)
Oozageer, Laticia (author)
Pascoe, Laura (author)
Paternoster, Lavinia (author)
Polasek, Ozren (author)
Ripatti, Samuli (author)
Sarzynski, Mark A. (author)
Shin, Chan Soo (author)
Narancic, Nina Smolej (author)
Spira, Dominik (author)
Srikanth, Priya (author)
Steinhagen-Thiessen, Elisabeth (author)
Sung, Yun Ju (author)
Swart, Karin M. A. (author)
Taittonen, Leena (author)
Tanaka, Toshiko (author)
Tikkanen, Emmi (author)
van der Velde, Nathalie (author)
van Schoor, Natasja M. (author)
Verweij, Niek (author)
Wright, Alan F. (author)
Yu, Lei (author)
Zmuda, Joseph M. (author)
Eklund, Niina (author)
Forrester, Terrence (author)
Grarup, Niels (author)
Jackson, Anne U. (author)
Kristiansson, Kati (author)
Kuulasmaa, Teemu (author)
Kuusisto, Johanna (author)
Lichtner, Peter (author)
Luan, Jian'an (author)
Mahajan, Anubha (author)
Mannisto, Satu (author)
Palmer, Cameron D. (author)
Ried, Janina S. (author)
Scott, Robert A. (author)
Stancakova, Alena (author)
Wagner, Peter J. (author)
Demirkan, Ayse (author)
Doring, Angela (author)
Gudnason, Vilmundur (author)
Kiel, Douglas P. (author)
Kuhnel, Brigitte (author)
Mangino, Massimo (author)
Mcknight, Barbara (author)
Menni, Cristina (author)
O'Connell, Jeffrey R. (author)
Oostra, Ben A. (author)
Shuldiner, Alan R. (author)
Song, Kijoung (author)
Vandenput, Liesbeth (author)
van Duijn, Cornelia M. (author)
Vollenweider, Peter (author)
White, Charles C. (author)
Boehnke, Michael (author)
Boettcher, Yvonne (author)
Cooper, Richard S. (author)
Forouhi, Nita G. (author)
Gieger, Christian (author)
Grallert, Harald (author)
Hingorani, Aroon (author)
Jorgensen, Torben (author)
Jousilahti, Pekka (author)
Kivimaki, Mika (author)
Kumari, Meena (author)
Laakso, Markku (author)
Langenberg, Claudia (author)
Linneberg, Allan (author)
Luke, Amy (author)
Mckenzie, Colin A. (author)
Palotie, Aarno (author)
Pedersen, Oluf (author)
Peters, Annette (author)
Strauch, Konstantin (author)
Tayo, Bamidele O. (author)
Wareham, Nicholas J. (author)
Bennett, David A. (author)
Bertram, Lars (author)
Blangero, John (author)
Bluher, Matthias (author)
Bouchard, Claude (author)
Campbell, Harry (author)
Cho, Nam H. (author)
Cummings, Steven R. (author)
Czerwinski, Stefan A. (author)
Demuth, Ilja (author)
Eckardt, Rahel (author)
Eriksson, Johan G. (author)
Ferrucci, Luigi (author)
Franco, Oscar H. (author)
Froguel, Philippe (author)
Gansevoort, Ron T. (author)
Hansen, Torben (author)
Harris, Tamara B. (author)
Hastie, Nicholas (author)
Heliovaara, Markku (author)
Hofman, Albert (author)
Jordan, Joanne M. (author)
Jula, Antti (author)
Kahonen, Mika (author)
Kajantie, Eero (author)
Knekt, Paul B. (author)
Koskinen, Seppo (author)
Kovacs, Peter (author)
Lehtimaki, Terho (author)
Lind, Lars (author)
Liu, Yongmei (author)
Orwoll, Eric S. (author)
Osmond, Clive (author)
Perola, Markus (author)
Perusse, Louis (author)
Raitakari, Olli T. (author)
Rankinen, Tuomo (author)
Rao, D. C. (author)
Rice, Treva K. (author)
Rivadeneira, Fernando (author)
Rudan, Igor (author)
Salomaa, Veikko (author)
Sorensen, Thorkild I. A. (author)
Stumvoll, Michael (author)
Tonjes, Anke (author)
Towne, Bradford (author)
Tranah, Gregory J. (author)
Tremblay, Angelo (author)
Uitterlinden, Andre G. (author)
van der Harst, Pim (author)
Vartiainen, Erkki (author)
Viikari, Jorma S. (author)
Vitart, Veronique (author)
Vohl, Marie-Claude (author)
Volzke, Henry (author)
Walker, Mark (author)
Wallaschofski, Henri (author)
Wild, Sarah (author)
Wilson, James F. (author)
Yengo, Loic (author)
Bishop, D. Timothy (author)
Borecki, Ingrid B. (author)
Chambers, John C. (author)
Cupples, L. Adrienne (author)
Dehghan, Abbas (author)
Deloukas, Panos (author)
Fatemifar, Ghazaleh (author)
Fox, Caroline (author)
Furey, Terrence S. (author)
Franke, Lude (author)
Han, Jiali (author)
Hunter, David J. (author)
Karjalainen, Juha (author)
Karpe, Fredrik (author)
Kaplan, Robert C. (author)
Kooner, Jaspal S. (author)
McCarthy, Mark I. (author)
Murabito, Joanne M. (author)
Morris, Andrew P. (author)
Bishop, Julia A. N. (author)
North, Kari E. (author)
Ohlsson, Claes (author)
Ong, Ken K. (author)
Prokopenko, Inga (author)
Richards, J. Brent (author)
Schadt, Eric E. (author)
Spector, Tim D. (author)
Widen, Elisabeth (author)
Willer, Cristen J. (author)
Yang, Jian (author)
Ingelsson, Erik (author)
Mohlke, Karen L. (author)
Hirschhorn, Joel N. (author)
Pospisilik, John Andrew (author)
Zillikens, M. Carola (author)
Lindgren, Cecilia (author)
Kilpelainen, Tuomas Oskari (author)
Loos, Ruth J. F. (author)
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 (publisher)
 (publisher)
2016
2016
English.
In: Nature Communications. - 2041-1723. ; 7
  • swepub:Mat__t
Abstract Subject headings
Close  
  • Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Keyword

Polymorphism
Obesity: metabolism
Obesity: genetics
Insulin: secretion
Insulin: metabolism
Glutamic Acid: metabolism
Genetic Predisposition to Disease: genetics
Europe: ethnology
Energy Metabolism: genetics
Continental Population Groups: genetics
Adipogenesis: genetics
Adiposity: genetics
Single Nucleotide: genetics
Quantitative Trait Loci: genetics
Synapses: metabolism
body mass; copy number variation; disease course; energy metabolism; gene expression; gene frequency; gene linkage disequilibrium; genetic association; genetic variability; heredity; human; insulin release; nonhuman; obesity; phenotype; priority journal; quantitative trait locus; receiver operating characteristic
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art (subject category)
ref (subject category)

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Lu, Yingchang
Day, Felix R.
Gustafsson, Stef ...
Buchkovich, Mart ...
Na, Jianbo
Bataille, Veroni ...
show more...
Cousminer, Diana ...
Dastani, Zari
Drong, Alexander ...
Esko, Tonu
Evans, David M.
Falchi, Mario
Feitosa, Mary F.
Ferreira, Teresa
Hedman, Asa K.
Haring, Robin
Hysi, Pirro G.
Iles, Mark M.
Justice, Anne E.
Kanoni, Stavroul ...
Lagou, Vasiliki
Li, Rui
Li, Xin
Locke, Adam
Lu, Chen
Magi, Reedik
Perry, John R. B ...
Pers, Tune H.
Qi, Qibin
Sanna, Marianna
Schmidt, Ellen M ...
Scott, William R ...
Shungin, Dmitry
Teumer, Alexande ...
Vinkhuyzen, Anna ...
Walker, Ryan W.
Westra, Harm-Jan
Zhang, Mingfeng
Zhang, Weihua
Zhao, Jing Hua
Zhu, Zhihong
Afzal, Uzma
Ahluwalia, Tarun ...
Bakker, Stephan ...
Bellis, Claire
Bonnefond, Ameli ...
Borodulin, Katja
Buchman, Aron S.
Cederholm, Tommy
Choh, Audrey C.
Choi, Hyung Jin
Curran, Joanne E ...
de Groot, Lisett ...
De Jager, Philip ...
Dhonukshe-Rutten ...
Enneman, Anke W.
Eury, Elodie
Evans, Daniel S.
Forsen, Tom
Friedrich, Nele
Fumeron, Frederi ...
Garcia, Melissa ...
Gartner, Simone
Han, Bok-Ghee
Havulinna, Aki S ...
Hayward, Carolin ...
Hernandez, Dena
Hillege, Hans
Ittermann, Till
Kent, Jack W.
Kolcic, Ivana
Laatikainen, Tii ...
Lahti, Jari
Leach, Irene Mat ...
Lee, Christine G ...
Lee, Jong-Young
Liu, Tian
Liu, Youfang
Lobbens, Stephan ...
Loh, Marie
Lyytikainen, Leo ...
Medina-Gomez, Ca ...
Michaelsson, Kar ...
Nalls, Mike A.
Nielson, Carrie ...
Oozageer, Latici ...
Pascoe, Laura
Paternoster, Lav ...
Polasek, Ozren
Ripatti, Samuli
Sarzynski, Mark ...
Shin, Chan Soo
Narancic, Nina S ...
Spira, Dominik
Srikanth, Priya
Steinhagen-Thies ...
Sung, Yun Ju
Swart, Karin M. ...
Taittonen, Leena
Tanaka, Toshiko
Tikkanen, Emmi
van der Velde, N ...
van Schoor, Nata ...
Verweij, Niek
Wright, Alan F.
Yu, Lei
Zmuda, Joseph M.
Eklund, Niina
Forrester, Terre ...
Grarup, Niels
Jackson, Anne U.
Kristiansson, Ka ...
Kuulasmaa, Teemu
Kuusisto, Johann ...
Lichtner, Peter
Luan, Jian'an
Mahajan, Anubha
Mannisto, Satu
Palmer, Cameron ...
Ried, Janina S.
Scott, Robert A.
Stancakova, Alen ...
Wagner, Peter J.
Demirkan, Ayse
Doring, Angela
Gudnason, Vilmun ...
Kiel, Douglas P.
Kuhnel, Brigitte
Mangino, Massimo
Mcknight, Barbar ...
Menni, Cristina
O'Connell, Jeffr ...
Oostra, Ben A.
Shuldiner, Alan ...
Song, Kijoung
Vandenput, Liesb ...
van Duijn, Corne ...
Vollenweider, Pe ...
White, Charles C ...
Boehnke, Michael
Boettcher, Yvonn ...
Cooper, Richard ...
Forouhi, Nita G.
Gieger, Christia ...
Grallert, Harald
Hingorani, Aroon
Jorgensen, Torbe ...
Jousilahti, Pekk ...
Kivimaki, Mika
Kumari, Meena
Laakso, Markku
Langenberg, Clau ...
Linneberg, Allan
Luke, Amy
Mckenzie, Colin ...
Palotie, Aarno
Pedersen, Oluf
Peters, Annette
Strauch, Konstan ...
Tayo, Bamidele O ...
Wareham, Nichola ...
Bennett, David A ...
Bertram, Lars
Blangero, John
Bluher, Matthias
Bouchard, Claude
Campbell, Harry
Cho, Nam H.
Cummings, Steven ...
Czerwinski, Stef ...
Demuth, Ilja
Eckardt, Rahel
Eriksson, Johan ...
Ferrucci, Luigi
Franco, Oscar H.
Froguel, Philipp ...
Gansevoort, Ron ...
Hansen, Torben
Harris, Tamara B ...
Hastie, Nicholas
Heliovaara, Mark ...
Hofman, Albert
Jordan, Joanne M ...
Jula, Antti
Kahonen, Mika
Kajantie, Eero
Knekt, Paul B.
Koskinen, Seppo
Kovacs, Peter
Lehtimaki, Terho
Lind, Lars
Liu, Yongmei
Orwoll, Eric S.
Osmond, Clive
Perola, Markus
Perusse, Louis
Raitakari, Olli ...
Rankinen, Tuomo
Rao, D. C.
Rice, Treva K.
Rivadeneira, Fer ...
Rudan, Igor
Salomaa, Veikko
Sorensen, Thorki ...
Stumvoll, Michae ...
Tonjes, Anke
Towne, Bradford
Tranah, Gregory ...
Tremblay, Angelo
Uitterlinden, An ...
van der Harst, P ...
Vartiainen, Erkk ...
Viikari, Jorma S ...
Vitart, Veroniqu ...
Vohl, Marie-Clau ...
Volzke, Henry
Walker, Mark
Wallaschofski, H ...
Wild, Sarah
Wilson, James F.
Yengo, Loic
Bishop, D. Timot ...
Borecki, Ingrid ...
Chambers, John C ...
Cupples, L. Adri ...
Dehghan, Abbas
Deloukas, Panos
Fatemifar, Ghaza ...
Fox, Caroline
Furey, Terrence ...
Franke, Lude
Han, Jiali
Hunter, David J.
Karjalainen, Juh ...
Karpe, Fredrik
Kaplan, Robert C ...
Kooner, Jaspal S ...
McCarthy, Mark I ...
Murabito, Joanne ...
Morris, Andrew P ...
Bishop, Julia A. ...
North, Kari E.
Ohlsson, Claes
Ong, Ken K.
Prokopenko, Inga
Richards, J. Bre ...
Schadt, Eric E.
Spector, Tim D.
Widen, Elisabeth
Willer, Cristen ...
Yang, Jian
Ingelsson, Erik
Mohlke, Karen L.
Hirschhorn, Joel ...
Pospisilik, John ...
Zillikens, M. Ca ...
Lindgren, Cecili ...
Kilpelainen, Tuo ...
Loos, Ruth J. F.
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