Genetics of monogenic obesity part 2 of 2, the Melanocortin 4 receptor gene (MC4R) / Johannes Hebebrand and Anke Hinney.

• Contents: The melanocortin 4 receptor gene (MC4R): mutations and polymorphisms -- Disruption of the Mc4r gene results in rodent obesity -- Functional implications of MC4R mutations -- Major gene for obesity -- Pedigree analyses for effect size quantification -- MC4R mutations in a population based sample -- MC4R in 1000 genomes -- Non-synonymous MC4R mutations in patients with both ADHD and obesity: 2 case reports -- MC4R as a polygene.

Subject headings

Human molecular genetics.  (LCSH)

Obesity  -- Genetic aspects. (LCSH)

Obesity  -- Genetic disorders. (LCSH)

Attention Deficit Disorder with Hyperactivity.  (MeSH)

Comorbidity.  (MeSH)

Genetic Predisposition to Disease.  (MeSH)

Molecular Biology.  (MeSH)

Polymorphism, Genetic.  (MeSH)

Adiposity  -- genetics. (MeSH)

Body Weight  -- genetics. (MeSH)

Obesity  -- complications. (MeSH)

Obesity  -- genetics. (MeSH)

Receptor, Melanocortin, Type 4  -- genetics. (MeSH)