Endostatin, Cathepsin S, and Cathepsin L, and Their Association with Inflammatory Markers and Mortality in Patients Undergoing Hemodialysis

• BACKGROUND/AIMS: Although both endostatin and cathepsins S have been associated with higher mortality, data in patients with end-stage renal disease (ESRD) are scarce. METHODS: A longitudinal cohort study of 207 prevalent patients undergoing hemodialysis. RESULTS: Cathepsins S and L were associated with soluble receptors for tumor necrosis factor (sTNFR1 and sTNFR2, rho between 0.28 and 0.43, p < 0.001 for all). Weaker or absent associations between endostatin, cathepsins S and L were seen with other inflammatory biomarkers, that is, CRP, interleukin 6, pentraxin 3, and TNF. In Cox and Laplace regression models adjusted for age, sex, dialysis vintage, and diabetes: standard deviation increments of endostatin was associated with a lower mortality (hazard ratio 0.75, 95% confidence interval (CI) 0.57-0.98), and with 6.8 months longer median survival. CONCLUSIONS: The high levels of endostatin, cathepsins S and L, and their associations with sTNFR1 and sTNFR2 warrant further studies exploring mortality, and the angiogenic and inflammatory pathways in ESRD.

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Medical and Health Sciences  (hsv)

Health Sciences  (hsv)

Public Health, Global Health, Social Medicine and Epidemiology  (hsv)

Medicin och hälsovetenskap  (hsv)

Hälsovetenskaper  (hsv)

Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi  (hsv)

Medical and Health Sciences  (hsv)

Clinical Medicine  (hsv)

Hematology  (hsv)

Medicin och hälsovetenskap  (hsv)

Klinisk medicin  (hsv)

Hematologi  (hsv)