SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Sundstrom Johan)
 

Sökning: WFRF:(Sundstrom Johan) > Association Between...

  • Hasvold, Pal (författare)

Association Between Paradoxical HDL Cholesterol Decrease and Risk of Major Adverse Cardiovascular Events in Patients Initiated on Statin Treatment in a Primary Care Setting

  • E-artikel/E-kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • 2016

Nummerbeteckningar

  • LIBRIS-ID:20515385
  • http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281478uri
  • urn:nbn:se:uu:diva-281478urn
  • 10.1007/s40261-015-0372-9doi

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Anmärkningar

  • Published
  • AstraZeneca
  • gratis
  • Background and Objectives Statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are unrelated. Many patients initiated on statins experience a paradoxical decrease in HDL-C. The aim of this study was to evaluate the association between a decrease in HDL-C and risk of major adverse cardiovascular events (MACE). Methods Data from 15,357 primary care patients initiated on statins during 2004-2009 were linked with data from mandatory national hospital, drug-dispensing, and cause-of-death registers, and were grouped according to HDL-C change: decreased >= 0.1 mmol/L, unchanged +/- 0.1 or >= 0.1 mmol/L increased. To evaluate the association between decrease in HDL-C and risk of MACE, a sample of propensity score-matched patients from the decreased and unchanged groups was created, using the latter group as reference. MACE was defined as myocardial infarction, unstable angina pectoris, ischaemic stroke, or cardiovascular mortality. Cox proportional hazards models were used to estimate relative risks. Results HDL-C decreased in 20 %, was unchanged in 58%, and increased in 22 % of patients initiated on statin treatment (96 % treated with simvastatin). The propensity score-matched sample comprised 5950 patients with mean baseline HDL-C and LDL-C of 1.69 and 4.53 mmol/L, respectively. HDL-C decrease was associated with 56 % higher MACE risk (hazard ratio 1.56; 95 % confidence interval 1.12-2.16; p < 0.01) compared with the unchanged HDL-C group. Conclusions Paradoxical statin-induced reduction in HDL-C was relatively common and was associated with increased risk of MACE.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Thuresson, Marcus (författare)
  • Sundstrom, Johan (författare)
  • Hammar, Niklas (författare)
  • Kjeldsen, Sverre E. (författare)
  • Johansson, Gunnar (författare)
  • Holme, Ingar (författare)
  • Bodegard, Johan (författare)
  • Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (utgivare)
  • Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (utgivare)
  • Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (utgivare)

Sammanhörande titlar

  • Del av/supplement till:channel record
  • Ingår i:VärdpublikationClinical drug investigation36:3, 225-2331173-2563

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy