Chemical biology of glycoproteins / edited by Zhongping Tan, Lai-Xi Wang.

• Introduction: General Aspects of the Chemical Biology of Glycoproteins / Patrick K. Chaffey, Xiaoyang Guan, Lai-Xi Wang and Zhongping Tan -- Chemical Biology of Protein N-Glycosylation / Chao Li and Lai-Xi Wang -- Chemical Biology of Protein O-Glycosylation / Patrick K. Chaffey, Lianli Chi and Zhongping Tan -- Chemical Biology of O-GlcNAc Glycosylation / Nathan J. Cox, Thomas R. Meister and Michael Boyce -- Chemical Synthesis and Engineering of N-Linked Glycoproteins / Hongxing Li, Yuankun Dao and Suwei Dong -- Chemoenzymatic Synthesis of N-Glycans / Xuefeng Cao, Jun Zhou, Yuxi Guo, Yunpeng Liu, Lei Li and Peng George Wang -- Towards Synthesis of Heparan Sulfate Glycopeptides and Proteoglycans / Sherif Ramadan, Weizhun Yang and Xuefei Huang -- Chemoenzymatic Synthesis of Low-Molecular-Weight Heparin and Heparan Sulfate / Xing Zhang and Robert J. Linhardt -- Synthetic Studies of GPI-Anchored Peptides, Glycopeptides, and Proteins / Jian Gao and Zhongwu Guo -- Chemical Approaches to Image Protein Glycosylation / Wei Lin, Ling Gao, Ke Qin and Xing Chen -- Targeting Glycans of HIV Envelope Glycoproteins for Vaccine Design / Anna-Janina Behrens, Gemma E. Seabright and Max Crispin -- Design, Synthesis and Evaluation of Mucin Glycopeptide Based Cancer Vaccine / Zhanyi Sun, Puguang Chen, Yanfang Liu and Yanmei Li -- Selective Chemical Glycosylation of Therapeutic Proteins / Qun Zhou. 

• Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions. Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers but recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.

Ämnesord

Glycoproteins.  (LCSH)

Genre

Electronic books 

Publikations- och innehållstyp

572.68 (DDC)

Ue.04823 (kssb/8 (machine generated))