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Large scale meta-an...
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
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Tsoi, Lam C. (author)
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Stuart, Philip E. (author)
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Tian, Chao (author)
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show more...
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Gudjonsson, Johann E. (author)
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Das, Sayantan (author)
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Zawistowski, Matthew (author)
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Ellinghaus, Eva (author)
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Barker, Jonathan N. (author)
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Chandran, Vinod (author)
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Dand, Nick (author)
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Callis Duffin, Kristina (author)
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Enerbäck, Charlotta (author)
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Esko, Tonu (author)
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Franke, Andre (author)
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Gladman, Dafna D. (author)
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Hoffmann, Per (author)
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Kingo, Kulli (author)
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Koks, Sulev (author)
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Krueger, Gerald G. (author)
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Lim, Henry W. (author)
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Metspalu, Andres (author)
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Mrowietz, Ulrich (author)
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Mucha, Soren (author)
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Rahman, Proton (author)
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Reis, Andre (author)
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Tejasvi, Trilokraj (author)
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Trembath, Richard (author)
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Voorhees, John J. (author)
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Weidinger, Stephan (author)
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Weichenthal, Michael (author)
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Wen, Xiaoquan (author)
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Eriksson, Nicholas (author)
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Kang, Hyun M. (author)
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Hinds, David A. (author)
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Nair, Rajan P. (author)
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Abecasis, Goncalo R. (author)
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Elder, James T. (author)
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- NATURE PUBLISHING GROUP 2017
- 2017
- English.
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In: Nature Communications. - 2041-1723. ; 8
Abstract
Subject headings
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- Psoriasis is a complex disease of skin with a prevalence of about 2%. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for psoriasis to date, including data from eight different Caucasian cohorts, with a combined effective sample size amp;gt;39,000 individuals. We identified 16 additional psoriasis susceptibility loci achieving genome-wide significance, increasing the number of identified loci to 63 for European-origin individuals. Functional analysis highlighted the roles of interferon signalling and the NFkB cascade, and we showed that the psoriasis signals are enriched in regulatory elements from different T cells (CD8(+) T-cells and CD4(+) T-cells including T(H)0, T(H)1 and T(H)17). The identified loci explain similar to 28% of the genetic heritability and generate a discriminatory genetic risk score (AUC = 0.76 in our sample) that is significantly correlated with age at onset (p = 2 x 10(-89)). This study provides a comprehensive layout for the genetic architecture of common variants for psoriasis.
Subject headings
- Medical and Health Sciences (hsv)
- Basic Medicine (hsv)
- Medical Genetics (hsv)
- Medicin och hälsovetenskap (hsv)
- Medicinska grundvetenskaper (hsv)
- Medicinsk genetik (hsv)
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- By the author/editor
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Tsoi, Lam C.
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Stuart, Philip E ...
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Tian, Chao
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Gudjonsson, Joha ...
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Das, Sayantan
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Zawistowski, Mat ...
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show more...
-
Ellinghaus, Eva
-
Barker, Jonathan ...
-
Chandran, Vinod
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Dand, Nick
-
Callis Duffin, K ...
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Enerbäck, Charlo ...
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Esko, Tonu
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Franke, Andre
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Gladman, Dafna D ...
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Hoffmann, Per
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Kingo, Kulli
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Koks, Sulev
-
Krueger, Gerald ...
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Lim, Henry W.
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Metspalu, Andres
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Mrowietz, Ulrich
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Mucha, Soren
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Rahman, Proton
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Reis, Andre
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Tejasvi, Trilokr ...
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Trembath, Richar ...
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Voorhees, John J ...
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Weidinger, Steph ...
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Weichenthal, Mic ...
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Wen, Xiaoquan
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Eriksson, Nichol ...
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Kang, Hyun M.
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Hinds, David A.
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Nair, Rajan P.
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Abecasis, Goncal ...
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Elder, James T.
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show less...
- By the university
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