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Early pregnancy sex...
Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer a nested case-control study in the Northern Sweden Maternity Cohort
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Fortner, Renee T. (författare)
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Tolockiene, Egle (författare)
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Schock, Helena (författare)
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Oda, Husam (författare)
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Lakso, Hans-Åke (författare)
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Hallmans, Göran (författare)
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Kaaks, Rudolf (författare)
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Toniolo, Paolo (författare)
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Zeleniuch-Jacquotte, Anne (författare)
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Grankvist, Kjell (författare)
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Lundin, Eva (författare)
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- 2017
- 2017
- Engelska.
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Ingår i: Breast Cancer Research. - 1465-5411. ; 19
Abstract
Ämnesord
Stäng
- Background: Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones. Methods: We conducted a nested case–control study in the Northern Sweden Maternity Cohort (1975–2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection). Estrogen receptor (ER) and progesterone receptor (PR) status was available for all cases; androgen receptor (AR) data were available for 41% of cases ( n = 92). Sex steroids were quantified by high-performance liquid chromatography tandem mass spectrometry. Odds ratios (ORs) and 95% confidence intervals were estimated using conditional logistic regression. Results: Higher concentrations of circulating progesterone in early pregnancy were inversely associated with ER+/PR+ breast cancer risk (ORlog2: 0.64 (0.41–1.00)). Higher testosterone was positively associated with ER+/PR+ disease risk (ORlog2: 1.57 (1.13–2.18)). Early pregnancy estrogens were not associated with risk, except for relatively high estradiol in the context of low progesterone (split at median, relative to low concentrations of both; OR: 1.87 (1.11–3.16)). None of the investigated hormones were associated with ER–/PR– disease, or with AR+ or AR+/ER+/PR+ disease. Conclusions: Consistent with experimental models, high progesterone in early pregnancy was associated with lower risk of ER+/PR+ breast cancer in the mother. High circulating testosterone in early pregnancy, which likely reflects nonpregnant premenopausal exposure, was associated with higher risk of ER+/PR+ disease.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Cancer and Oncology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Cancer och onkologi (hsv)
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Obstetrics, Gynecology and Reproductive Medicine (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Reproduktionsmedicin och gynekologi (hsv)
Nyckelord
- Endogenous hormones
- Early pregnancy
- Breast cancer
- Sex steroids
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Till lärosätets databas
- Av författaren/redakt...
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Fortner, Renee T ...
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Tolockiene, Egle
-
Schock, Helena
-
Oda, Husam
-
Lakso, Hans-Åke
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Hallmans, Göran
-
visa fler...
-
Kaaks, Rudolf
-
Toniolo, Paolo
-
Zeleniuch-Jacquo ...
-
Grankvist, Kjell
-
Lundin, Eva
-
visa färre...
- Av lärosätet
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