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WFRF:(Harris Tamara B.)
 

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Discovery and refinement of loci associated with lipid levels

Willer, Cristen J. (author)
Schmidt, Ellen M. (author)
Sengupta, Sebanti (author)
show more...
Peloso, Gina M. (author)
Gustafsson, Stefan (author)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Kanoni, Stavroula (author)
Ganna, Andrea (author)
Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Chen, Jin (author)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Mora, Samia (author)
Beckmann, Jacques S. (author)
Bragg-Gresham, Jennifer L. (author)
Chang, Hsing-Yi (author)
Demirkan, Ayse (author)
Den Hertog, Heleen M. (author)
Do, Ron (author)
Donnelly, Louise A. (author)
Ehret, Georg B. (author)
Esko, Tonu (author)
Feitosa, Mary F. (author)
Ferreira, Teresa (author)
Fischer, Krista (author)
Fontanillas, Pierre (author)
Fraser, Ross M. (author)
Freitag, Daniel F. (author)
Gurdasani, Deepti (author)
Heikkila, Kauko (author)
Hyppoenen, Elina (author)
Isaacs, Aaron (author)
Jackson, Anne U. (author)
Johansson, Åsa (author)
Uppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)
Johnson, Toby (author)
Kaakinen, Marika (author)
Kettunen, Johannes (author)
Kleber, Marcus E. (author)
Li, Xiaohui (author)
Luan, Jian'an (author)
Lyytikainen, Leo-Pekka (author)
Magnusson, Patrik K. E. (author)
Karolinska Institutet
Mangino, Massimo (author)
Mihailov, Evelin (author)
Montasser, May E. (author)
Mueller-Nurasyid, Martina (author)
Nolte, Ilja M. (author)
O'Connell, Jeffrey R. (author)
Palmer, Cameron D. (author)
Perola, Markus (author)
Petersen, Ann-Kristin (author)
Sanna, Serena (author)
Saxena, Richa (author)
Service, Susan K. (author)
Shah, Sonia (author)
Shungin, Dmitry (author)
Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi
Sidore, Carlo (author)
Song, Ci (author)
Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Strawbridge, Rona J. (author)
Karolinska Institutet
Surakka, Ida (author)
Tanaka, Toshiko (author)
Teslovich, Tanya M. (author)
Thorleifsson, Gudmar (author)
Van den Herik, Evita G. (author)
Voight, Benjamin F. (author)
Volcik, Kelly A. (author)
Waite, Lindsay L. (author)
Wong, Andrew (author)
Wu, Ying (author)
Zhang, Weihua (author)
Absher, Devin (author)
Asiki, Gershim (author)
Barroso, Ines (author)
Been, Latonya F. (author)
Bolton, Jennifer L. (author)
Bonnycastle, Lori L. (author)
Brambilla, Paolo (author)
Burnett, Mary S. (author)
Cesana, Giancarlo (author)
Dimitriou, Maria (author)
Doney, Alex S. F. (author)
Doering, Angela (author)
Elliott, Paul (author)
Epstein, Stephen E. (author)
Eyjolfsson, Gudmundur Ingi (author)
Gigante, Bruna (author)
Karolinska Institutet
Goodarzi, Mark O. (author)
Grallert, Harald (author)
Gravito, Martha L. (author)
Groves, Christopher J. (author)
Hallmans, Göran (author)
Umeå universitet,Näringsforskning
Hartikainen, Anna-Liisa (author)
Hayward, Caroline (author)
Hernandez, Dena (author)
Hicks, Andrew A. (author)
Holm, Hilma (author)
Hung, Yi-Jen (author)
Illig, Thomas (author)
Jones, Michelle R. (author)
Kaleebu, Pontiano (author)
Kastelein, John J. P. (author)
Khaw, Kay-Tee (author)
Kim, Eric (author)
Klopp, Norman (author)
Komulainen, Pirjo (author)
Kumari, Meena (author)
Langenberg, Claudia (author)
Lehtimaki, Terho (author)
Lin, Shih-Yi (author)
Lindstrom, Jaana (author)
Loos, Ruth J. F. (author)
Mach, Francois (author)
McArdle, Wendy L. (author)
Meisinger, Christa (author)
Mitchell, Braxton D. (author)
Mueller, Gabrielle (author)
Nagaraja, Ramaiah (author)
Narisu, Narisu (author)
Karolinska Institutet
Nieminen, Tuomo V. M. (author)
Nsubuga, Rebecca N. (author)
Olafsson, Isleifur (author)
Ong, Ken K. (author)
Palotie, Aarno (author)
Papamarkou, Theodore (author)
Pomilla, Cristina (author)
Pouta, Anneli (author)
Rader, Daniel J. (author)
Reilly, Muredach P. (author)
Ridker, Paul M. (author)
Rivadeneira, Fernando (author)
Rudan, Igor (author)
Ruokonen, Aimo (author)
Samani, Nilesh (author)
Scharnagl, Hubert (author)
Seeley, Janet (author)
Silander, Kaisa (author)
Stancakova, Alena (author)
Stirrups, Kathleen (author)
Swift, Amy J. (author)
Tiret, Laurence (author)
Uitterlinden, Andre G. (author)
van Pelt, L. Joost (author)
Vedantam, Sailaja (author)
Wainwright, Nicholas (author)
Wijmenga, Cisca (author)
Wild, Sarah H. (author)
Willemsen, Gonneke (author)
Wilsgaard, Tom (author)
Wilson, James F. (author)
Young, Elizabeth H. (author)
Zhao, Jing Hua (author)
Adair, Linda S. (author)
Arveiler, Dominique (author)
Assimes, Themistocles L. (author)
Bandinelli, Stefania (author)
Bennett, Franklyn (author)
Bochud, Murielle (author)
Boehm, Bernhard O. (author)
Boomsma, Dorret I. (author)
Borecki, Ingrid B. (author)
Bornstein, Stefan R. (author)
Bovet, Pascal (author)
Burnier, Michel (author)
Campbell, Harry (author)
Chakravarti, Aravinda (author)
Chambers, John C. (author)
Chen, Yii-Der Ida (author)
Collins, Francis S. (author)
Cooper, Richard S. (author)
Danesh, John (author)
Dedoussis, George (author)
de Faire, Ulf (author)
Karolinska Institutet
Feranil, Alan B. (author)
Ferrieres, Jean (author)
Ferrucci, Luigi (author)
Freimer, Nelson B. (author)
Gieger, Christian (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Gudnason, Vilmundur (author)
Gyllensten, Ulf (author)
Uppsala universitet,Genomik
Hamsten, Anders (author)
Karolinska Institutet
Harris, Tamara B. (author)
Hingorani, Aroon (author)
Hirschhorn, Joel N. (author)
Hofman, Albert (author)
Hovingh, G. Kees (author)
Hsiung, Chao Agnes (author)
Humphries, Steve E. (author)
Hunt, Steven C. (author)
Hveem, Kristian (author)
Iribarren, Carlos (author)
Jarvelin, Marjo-Riitta (author)
Jula, Antti (author)
Kahonen, Mika (author)
Kaprio, Jaakko (author)
Kesaniemi, Antero (author)
Kivimaki, Mika (author)
Kooner, Jaspal S. (author)
Koudstaal, Peter J. (author)
Krauss, Ronald M. (author)
Kuh, Diana (author)
Kuusisto, Johanna (author)
Kyvik, Kirsten O. (author)
Laakso, Markku (author)
Lakka, Timo A. (author)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Lindgren, Cecilia M. (author)
Martin, Nicholas G. (author)
Maerz, Winfried (author)
McCarthy, Mark I. (author)
McKenzie, Colin A. (author)
Meneton, Pierre (author)
Metspalu, Andres (author)
Moilanen, Leena (author)
Morris, Andrew D. (author)
Munroe, Patricia B. (author)
Njolstad, Inger (author)
Pedersen, Nancy L. (author)
Power, Chris (author)
Pramstaller, Peter P. (author)
Price, Jackie F. (author)
Psaty, Bruce M. (author)
Quertermous, Thomas (author)
Rauramaa, Rainer (author)
Saleheen, Danish (author)
Salomaa, Veikko (author)
Sanghera, Dharambir K. (author)
Saramies, Jouko (author)
Schwarz, Peter E. H. (author)
Sheu, Wayne H-H (author)
Shuldiner, Alan R. (author)
Siegbahn, Agneta (author)
Uppsala universitet,Molekylär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Koagulation och inflammationsvetenskap
Spector, Tim D. (author)
Stefansson, Kari (author)
Strachan, David P. (author)
Tayo, Bamidele O. (author)
Tremoli, Elena (author)
Tuomilehto, Jaakko (author)
Uusitupa, Matti (author)
van Duijn, Cornelia M. (author)
Vollenweider, Peter (author)
Wallentin, Lars (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
Wareham, Nicholas J. (author)
Whitfield, John B. (author)
Wolffenbuttel, Bruce H. R. (author)
Ordovas, Jose M. (author)
Boerwinkle, Eric (author)
Palmer, Colin N. A. (author)
Thorsteinsdottir, Unnur (author)
Chasman, Daniel I. (author)
Rotter, Jerome I. (author)
Franks, Paul (author)
Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Lunds universitet, Harvard University
Ripatti, Samuli (author)
Cupples, L. Adrienne (author)
Sandhu, Manjinder S. (author)
Rich, Stephen S. (author)
Boehnke, Michael (author)
Deloukas, Panos (author)
Kathiresan, Sekar (author)
Mohlke, Karen L. (author)
Ingelsson, Erik (author)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
Abecasis, Goncalo R. (author)
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 (creator_code:org_t)
2013-10-06
2013
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:11, s. 1274-1283
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 x 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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