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Radiologic-Histopat...
Radiologic-Histopathologic Correlation of Cerebral Microbleeds Using Pre-Mortem and Post-Mortem MRI
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Haller, Sven (författare)
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Montandon, Marie-Louise (författare)
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Lazeyras, François (författare)
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Scheffler, Max (författare)
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Meckel, Stephan (författare)
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Herrmann, Francois R (författare)
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Giannakopoulos, Panteleimon (författare)
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Kövari, Enikö (författare)
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visa färre...
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(utgivare)
- 2016
- 2016
- Engelska.
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Ingår i: PLoS ONE. - 1932-6203. ; 11:12
Abstract
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- INTRODUCTION: Cerebral microbleeds (CMB), also known as cerebral microhemorrhages, are small areas of susceptibility on brain magnetic resonance imaging (MRI), that are increasingly detected due to the higher availability of high-field MRI systems and dedicated pulse sequences. The prevalence of CMBs increases in cases with cognitive decline. The current investigation assessed the poorly investigated radiologic-histopathologic correlation of CMBs on MRI. METHODS: The local ethical committee approved the current investigation. We retrospectively assessed a consecutive series of 1303 autopsy cases hospitalized in Geneva University Hospitals between 2000-2014. Of 112 cases with pre-mortem T2* sequences, we included 25 cases (mean age 77.3 ± 9.6, 9 females) with at least one CMB. We compared pre-mortem CMBs with targeted histopathology and post-mortem MRI. RESULTS: 25 cases had 31 CMB lesions detected by pre-mortem MRI. 25 additional CMB were detected on histopathology. 4 CMBs on pre-mortem MRI were false positives, resulting in a total of 52 CMBs. 27 CMBs on pre-mortem MRI were confirmed on histopathology, corresponding to a sensitivity or true positive rate of 51.9% (95% CI 37.6-66.0%). The false negative rate of pre-mortem MRI was 48.1% (95% CI 34.0-62.4%). Post-mortem MRI showed only 3 cases with additional CMBs. Overall, pre-mortem MRI significantly underestimated CMBs (p = 0.0001). CONCLUSIONS: Routine clinical brain MRI underestimates the prevalence of CMBs by approximately 50%, and 12% of radiologic pre-mortem MRI CMBs were false positives. Post-mortem MRI confirmed that this discordance is not explained by microbleeds occurring after the pre-mortem MRI.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Radiology, Nuclear Medicine and Medical Imaging (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Radiologi och bildbehandling (hsv)
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