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Sökning: WFRF:(Rohrmann Sabine) > (2014) > Obesity and cancer

  • Shanmugalingam, Thurkaa (författare)

Obesity and cancer the role of vitamin D

  • E-artikel/E-kapitelEngelska2014

Förlag, utgivningsår, omfång ...

  • 2014

Nummerbeteckningar

  • LIBRIS-ID:22068259
  • http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235324uri
  • urn:nbn:se:uu:diva-235324urn
  • 10.1186/1471-2407-14-712doi

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  • Språk:engelska

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Anmärkningar

  • Published
  • gratis
  • Background: It is estimated that 20% of all cancer cases are caused by obesity. Vitamin D is thought to be one of the mechanisms underlying this association. This review aims to summarise the evidence for the mediating effect of vitamin D on the link between obesity and cancer. Methods: Three literature searches using PubMed and Embase were conducted to assess whether vitamin D plays an important role in the pathway between obesity and cancer: (1) obesity and cancer; (2) obesity and vitamin D; and (3) vitamin D and cancer. A systematic review was performed for (1) and (3), whereas a meta-analysis including random effects analyses was performed for (2). Results: (1) 32 meta-analyses on obesity and cancer were identified; the majority reported a positive association between obesity and risk of cancer. (2) Our meta-analysis included 12 original studies showing a pooled relative risk of 1.52 (95% CI: 1.33-1.73) for risk of vitamin D deficiency (<50 nmol/L) in obese people (body mass index >30 kg/m(2)). (3) 21 meta-analyses on circulating vitamin D levels and cancer risk were identified with different results for different types of cancer. Conclusion: There is consistent evidence for a link between obesity and cancer as well as obesity and low vitamin D. However, it seems like the significance of the mediating role of vitamin D in the biological pathways linking obesity and cancer is low. There is a need for a study including all three components while dealing with bias related to dietary supplements and vitamin D receptor polymorphisms.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Crawley, Danielle (författare)
  • Bosco, Cecilia (författare)
  • Melvin, Jennifer (författare)
  • Rohrmann, Sabine (författare)
  • Chowdhury, Simon (författare)
  • Holmberg, Lars (författare)
  • Van Hemelrijck, Mieke (författare)
  • Uppsala universitetMedicinska och farmaceutiska vetenskapsområdet (utgivare)

Sammanhörande titlar

  • Del av/supplement till:channel record
  • Ingår i:VärdpublikationBMC Cancer14, 7121471-2407

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