Control of Drosophila  blood cell activation via toll signaling in the fat body

Published
Vetenskapsrådet
gratis
The Toll signaling pathway, first discovered in Drosophila , has a well-established role in immune responses in insects as well as in mammals. In Drosophila , the Toll-dependent induction of antimicrobial peptide production has been intensely studied as a model for innate immune responses in general. Besides this humoral immune response, Toll signaling is also known to activate blood cells in a reaction that is similar to the cellular immune response to parasite infections, but the mechanisms of this response are poorly understood. Here we have studied this response in detail, and found that Toll signaling in several different tissues can activate a cellular immune defense, and that this response does not require Toll signaling in the blood cells themselves. Like in the humoral immune response, we show that Toll signaling in the fat body (analogous to the liver in vertebrates) is of major importance in the Toll-dependent activation of blood cells. However, this Toll-dependent mechanism of blood cell activation contributes very little to the immune response against the parasitoid wasp, Leptopilina boulardi , probably because the wasp is able to suppress Toll induction. Other redundant pathways may be more important in the defense against this pathogen.

Av författaren/redakt...: Schmid, Martin R ...; Anderl, Ines; Vesala, L; Vanha-aho, L-M; Deng, Xiao-Juan; Rämet, M; visa fler...; Hultmark, Dan; visa färre...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.