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The evolution of ve...
The evolution of vertebrate somatostatin receptors and their gene regions involves extensive chromosomal rearrangements.
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Ocampo Daza, Daniel (författare)
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Sundström, Görel (författare)
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Bergqvist, Christina (författare)
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visa fler...
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Larhammar, Dan (författare)
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visa färre...
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(utgivare)
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(medarbetare)
- 2012
- 2012
- Engelska.
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Ingår i: BMC Evolutionary Biology. - 1471-2148. ; 12, 231
Abstract
Ämnesord
Stäng
- Background: Somatostatin and its related neuroendocrine peptides have a wide varietyof physiological functions that are mediated by five somatostatin receptors with gene names SSTR1-5 in mammals. To resolve their evolution in vertebrates we have investigated the SSTR genes and a large number of adjacent gene families by phylogeny and conserved synteny analyses in a broad range of vertebrate species. Results: We find that the SSTRs form two families that belong to distinct paralogons. We observe not only chromosomal similarities reflecting the paralogy relationships between the SSTR-bearing chromosome regions, but also extensive rearrangements between these regions in teleost fish genomes, including fusions and translocations followed by reshuffling through intrachromosomalrearrangements. These events obscure the paralogy relationships but are still tractable thanks tothe many genomes now available. We have identified a previously unrecognized SSTR subtype, SSTR6, previously misidentified as either SSTR1 or SSTR4. Conclusions: Two ancestral SSTR-bearing chromosome regions were duplicated in the two basalvertebrate tetraploidizations (2R). One of these ancestral SSTR genes generated SSTR2, -3 and -5, the other gave rise to SSTR1, -4 and -6. Subsequently SSTR6 was lost in tetrapods and SSTR4 in teleosts. Our study shows that extensive chromosomal rearrangements have taken place between related chromosome regions in teleosts, but that these events can be resolved by investigating several distantly related species.
Ämnesord
- Natural Sciences (hsv)
- Biological Sciences (hsv)
- Naturvetenskap (hsv)
- Biologiska vetenskaper (hsv)
Nyckelord
- Somatostatin receptors
- Whole genome duplications
- Chromosome rearrangements
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